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PMID: 2950524 Published · ppublish English Journal Article

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 84 ·No. 5 ·1987-03-00 ·Pages 1374-8

Leo O, Foo M, Sachs DH, Samelson LE, Bluestone JA

Abstract

A monoclonal antibody (145-2C11) specific for the murine T3 complex was derived by immunizing Armenian hamsters with a murine cytolytic T-cell clone. The antibody is specific for a 25-kDa protein component (T3-epsilon) of the antigen-specific T-cell receptor. It reacts with all mature T cells and can both activate and inhibit T-cell function. These results identify T3-epsilon as a cell surface protein involved in the transduction of activation signals.

MeSH Terms
Animals Antibodies, Monoclonal Antigens, Surface/analysis CD3 Complex Cell Line Cricetinae Flow Cytometry Humans Mice Receptors, Antigen, T-Cell/immunology T-Lymphocytes/immunology T-Lymphocytes, Cytotoxic/immunology
Chemicals
Antibodies, Monoclonal Antigens, Surface CD3 Complex Receptors, Antigen, T-Cell
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Leo O
Foo M
Sachs D H
Samelson L E
Bluestone J A
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30 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.84.5.1374
Published
1987-03-00
Pages
1374-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC304432
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.84.5.1374 PMC Full Text View journal details
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