Quantitative aspects of the multiplication of influenza A virus in the mouse lung; relation between the degree of viral multiplication and the extent of pneumonia.
Influenza A virus, PR8 strain, increases in amount in the infected mouse lung at a relatively constant rate. When more than 25 M.S.50 doses of virus is inoculated, the rate of multiplication appears to be independent of the amount of virus introduced; has a value of 1,100-fold increase per day. The rate of increase in the pulmonary lesions induced by infection of the mouse lung with PR8 also appears to be relatively constant and independent of the amount of virus inoculated; has a value of 8.5-fold increase per day. The essential variables in the PR8-mouse lung system appear to be equated satisfactorily by functions which were derived previously (4) during a similar quantitative investigation on pneumonia virus of mice (PVM). Evidence in support of the hypothesis that the processes of multiplication of PR8 and PVM are different in the mouse lung is presented.
13 references, click to expand
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A resistant variant of mumps virus; multiplication of the variant in the presence of inhibitory quantities of Friedländer bacillus polysaccharide.J Exp Med. 1949 Nov;90(5):393-407 PMID: 18143585
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The inhibitory effect of polysaccharide on mumps virus multiplication.J Exp Med. 1948 May 1;87(5):385-410 PMID: 18912891
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The dependence of the pathological lesion upon the multiplication of pneumonia virus of mice (PVM); kinetic relation between the degree of viral multiplication and the extent of pneumonia.J Exp Med. 1951 Feb;93(2):139-50 PMID: 14803638
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STUDIES ON PNEUMONIA VIRUS OF MICE (PVM) : III. HEMAGGLUTINATION BY THE VIRUS; THE OCCURRENCE OF COMBINATION BETWEEN THE VIRUS AND A TISSUE SUBSTANCE.J Exp Med. 1946 Jan 31;83(2):105-32 PMID: 19871517
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Characteristics of the multiplication cycle of pneumonia virus of mice (PVM).J Exp Med. 1951 Feb;93(2):151-60 PMID: 14803639
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THE DEMONSTRATION OF ONE-STEP GROWTH CURVES OF INFLUENZA VIRUSES THROUGH THE BLOCKING EFFECT OF IRRADIATED VIRUS ON FURTHER INFECTION.J Exp Med. 1947 Oct 31;86(5):423-37 PMID: 19871688
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The relation of the Krebs cycle to viral synthesis. II. The effect of sodium fluoroacetate on the propagation of influenza virus in mice.J Exp Med. 1951 Jun;93(6):635-42 PMID: 14832407
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Concurrent infection with influenza virus and mumps virus or pneumonia virus of mice as bearing on the inhibition of virus multiplication by bacterial polysaccharides.J Exp Med. 1949 Jan;89(1):37-52 PMID: 18099164
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EXPERIMENTAL INFECTION WITH INFLUENZA A VIRUS IN MICE : THE INCREASE IN INTRAPULMONARY VIRUS AFTER INOCULATION AND THE INFLUENCE OF VARIOUS FACTORS THEREON.J Exp Med. 1941 Jan 1;73(1):43-55 PMID: 19871064
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THE MODIFYING EFFECTS OF CERTAIN SUBSTANCES OF BACTERIAL ORIGIN ON THE COURSE OF INFECTION WITH PNEUMONIA VIRUS OF MICE (PVM).J Exp Med. 1947 May 31;85(6):623-46 PMID: 19871640
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ADSORPTION OF INFLUENZA HEMAGGLUTININS AND VIRUS BY RED BLOOD CELLS.J Exp Med. 1942 Aug 1;76(2):195-209 PMID: 19871229
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NEUTRALIZATION OF EPIDEMIC INFLUENZA VIRUS : THE LINEAR RELATIONSHIP BETWEEN THE QUANTITY OF SERUM AND THE QUANTITY OF VIRUS NEUTRALIZED.J Exp Med. 1939 Jul 31;70(2):209-22 PMID: 19870902
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Therapy of infection with pneumonia virus of mice (PVM); effect of a polysaccharide on the multiplication cycles of the virus and on the course of the viral pneumonia.J Exp Med. 1951 Feb;93(2):161-71 PMID: 14803640
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