The effect of cortisone and adrenocorticotrophic hormone on the concentration of circulating antibody.

The Journal of experimental medicine ·Vol. 93 ·No. 1 ·1951-01-00 ·Pages 37-48

BJØRNEBOE M, FISCHEL EE, STOERK HC

Abstract

The administration of adrenocorticotrophic hormone and of cortisone was found to result in a reduction in the concentration of antipneumococcal antibody in the circulation of rabbits. This reduction occurred both when the hormones were administered at the beginning of immunization and after immunization was well advanced. Marked atrophic changes in lymphoid tissue and a diminution in the number of various types of mononuclear cells followed upon the hormone administration. The possible bearing of these observations on theories concerning the sites of antibody production is discussed.

Keywords

ACTH ANTIGENS AND ANTIBODIES CORTISONE

MeSH Terms

Adrenocorticotropic Hormone Antibodies Antigens Cortisone

Chemicals

Antibodies Antigens Adrenocorticotropic Hormone Cortisone

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

BJØRNEBOE M

FISCHEL E E

STOERK H C

References (10)

10 references, click to expand

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Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.93.1.37

Published

1951-01-00

Pages

37-48

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2136054

Subset

External Links

PubMed source DOI: 10.1084/jem.93.1.37 PMC Full Text View journal details

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The effect of cortisone and adrenocorticotrophic hormone on the concentration of circulating antibody.

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