Home LiteratureArticle Details
PMID: 14762059 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Comparative genomics of gene expression in the parasitic and free-living nematodes Strongyloides stercoralis and Caenorhabditis elegans.

Genome research ·Vol. 14 ·No. 2 ·2004-02-00 ·Pages 209-20

Mitreva M, McCarter JP, Martin J, Dante M, Wylie T, Chiapelli B, Pape D, Clifton SW, Nutman TB, Waterston RH

Abstract

Although developmental timing of gene expression is used to infer potential gene function, studies have yet to correlate this information between species. We analyzed 10,921 ESTs in 3311 clusters from first- and infective third-stage larva (L1, L3i) of the parasitic nematode Strongyloides stercoralis and compared the results to Caenorhabditis elegans, a species that has an L3i-like dauer stage. In the comparison of S. stercoralis clusters with stage-specific expression to C. elegans homologs expressed in either dauer or nondauer stages, matches between S. stercoralis L1 and C. elegans nondauer-expressed genes dominated, suggesting conservation in the repertoire of genes expressed during growth in nutrient-rich conditions. For example, S. stercoralis collagen transcripts were abundant in L1 but not L3i, a pattern consistent with C. elegans collagens. Although a greater proportion of S. stercoralis L3i than L1 genes have homologs among the C. elegans dauer-specific transcripts, we did not uncover evidence of a robust conserved L3i/dauer 'expression signature.' Strikingly, in comparisons of S. stercoralis clusters to C. elegans homologs with RNAi knockouts, those with significant L1-specific expression were more than twice as likely as L3i-specific clusters to match genes with phenotypes. We also provide functional classifications of S. stercoralis clusters.

MeSH Terms
Animals Caenorhabditis elegans/genetics,growth & development Cloning, Molecular Cluster Analysis Culture Media/chemistry,metabolism DNA, Helminth/genetics Gene Expression Profiling/methods,statistics & numerical data Genes, Helminth/genetics Genomics/methods Molecular Sequence Data Oligonucleotide Array Sequence Analysis/methods,statistics & numerical data Phenotype RNA Interference/physiology RNA, Helminth/genetics Sequence Analysis, DNA/methods,statistics & numerical data Sequence Homology, Nucleic Acid Species Specificity Strongyloides stercoralis/genetics,growth & development Transcription, Genetic/genetics
Chemicals
Culture Media DNA, Helminth RNA, Helminth
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Mitreva Makedonka
Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63108, USA. mmitreva@watson.wstl.edu
McCarter James P
Martin John
Dante Mike
Wylie Todd
Chiapelli Brandi
Pape Deana
Clifton Sandra W
Nutman Thomas B
Waterston Robert H
References (81)
81 references, click to expand
  1. Predictive value of an enzyme-linked immunosorbent assay (ELISA) for the serodiagnosis of strongyloidiasis.
    Am J Clin Pathol. 1988 Mar;89(3):391-4 PMID: 3348175
  2. Cloning and characterization of Ancylostoma-secreted protein. A novel protein associated with the transition to parasitism by infective hookworm larvae.
    J Biol Chem. 1996 Mar 22;271(12):6672-8 PMID: 8636085
  3. Albumin and a dialyzable serum factor stimulate feeding in vitro by third-stage larvae of the canine hookworm Ancylostoma caninum.
    J Parasitol. 1991 Aug;77(4):587-91 PMID: 1713962
  4. Syndrome of hyperinfection with Strongyloides stercoralis.
    Rev Infect Dis. 1981 May-Jun;3(3):397-407 PMID: 7025145
  5. Developmental switching in the parasitic nematode Strongyloides stercoralis is controlled by the ASF and ASI amphidial neurons.
    J Parasitol. 1998 Aug;84(4):691-5 PMID: 9714195
  6. Myotactin, a novel hypodermal protein involved in muscle-cell adhesion in Caenorhabditis elegans.
    J Cell Biol. 1999 Aug 9;146(3):659-72 PMID: 10444073
  7. Genome evolution and developmental constraint in Caenorhabditis elegans.
    Mol Biol Evol. 2002 May;19(5):728-35 PMID: 11961106
  8. A survey of genes expressed in adults of the human hookworm, Necator americanus.
    Parasitology. 2000 Feb;120 ( Pt 2):171-84 PMID: 10726278
  9. A gene expression map for Caenorhabditis elegans.
    Science. 2001 Sep 14;293(5537):2087-92 PMID: 11557892
  10. KEGG: kyoto encyclopedia of genes and genomes.
    Nucleic Acids Res. 2000 Jan 1;28(1):27-30 PMID: 10592173
  11. Generation and analysis of 280,000 human expressed sequence tags.
    Genome Res. 1996 Sep;6(9):807-28 PMID: 8889549
  12. daf-1, a C. elegans gene controlling dauer larva development, encodes a novel receptor protein kinase.
    Cell. 1990 May 18;61(4):635-45 PMID: 2160853
  13. daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans.
    Science. 1997 Nov 14;278(5341):1319-22 PMID: 9360933
  14. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans.
    Nature. 1998 Feb 19;391(6669):806-11 PMID: 9486653
  15. Rapid gene mapping in Caenorhabditis elegans using a high density polymorphism map.
    Nat Genet. 2001 Jun;28(2):160-4 PMID: 11381264
  16. Species-specific differences in heterogonic development of serially transferred free-living generations of Strongyloides planiceps and Strongyloides stercoralis.
    J Parasitol. 1991 Aug;77(4):592-4 PMID: 1865267
  17. High-throughput plasmid DNA purification for 3 cents per sample.
    Nucleic Acids Res. 1999 Dec 15;27(24):e37 PMID: 10572189
  18. A cloned antigen for serological diagnosis of Wuchereria bancrofti microfilaremia with daytime blood samples.
    Mol Biochem Parasitol. 1992 Dec;56(2):269-77 PMID: 1484551
  19. A proline-rich structural protein of the surface sheath of larval Brugia filarial nematode parasites.
    J Biol Chem. 1991 Jun 15;266(17):11002-8 PMID: 1710216
  20. Temporal reiteration of a precise gene expression pattern during nematode development.
    EMBO J. 1996 Jul 15;15(14):3633-9 PMID: 8670866
  21. Horizontally transferred genes in plant-parasitic nematodes: a high-throughput genomic approach.
    Genome Biol. 2003;4(6):R39 PMID: 12801413
  22. Transgene expression in Strongyloides stercoralis following gonadal microinjection of DNA constructs.
    Mol Biochem Parasitol. 2002 Feb;119(2):279-84 PMID: 11814580
  23. The cuticle of the nematode Caenorhabditis elegans: a complex collagen structure.
    Bioessays. 1994 Mar;16(3):171-8 PMID: 8166670
  24. Genome sequence of the nematode C. elegans: a platform for investigating biology.
    Science. 1998 Dec 11;282(5396):2012-8 PMID: 9851916
  25. Analysis of expressed sequence tags indicates 35,000 human genes.
    Nat Genet. 2000 Jun;25(2):232-4 PMID: 10835644
  26. Identification of abundantly expressed novel and conserved genes from the infective larval stage of Toxocara canis by an expressed sequence tag strategy.
    Infect Immun. 1999 Sep;67(9):4771-9 PMID: 10456930
  27. Serum immunoglobulin G4 antibodies to the recombinant antigen, Ll-SXP-1, are highly specific for Loa loa infection.
    J Infect Dis. 2003 Jan 1;187(1):128-33 PMID: 12508156
  28. Reconstruction of amino acid biosynthesis pathways from the complete genome sequence.
    Genome Res. 1998 Mar;8(3):203-10 PMID: 9521924
  29. 400000 nematode ESTs on the Net.
    Trends Parasitol. 2003 Jul;19(7):283-6 PMID: 12855373
  30. Immunoaffinity-isolated antigens induce protective immunity against larval Strongyloides stercoralis in mice.
    Exp Parasitol. 2002 Feb;100(2):112-20 PMID: 12054701
  31. Diagnosis of Strongyloides stercoralis infection.
    Clin Infect Dis. 2001 Oct 1;33(7):1040-7 PMID: 11528578
  32. Construction of cDNA libraries from limiting amounts of material.
    Curr Opin Biotechnol. 1994 Feb;5(1):34-9 PMID: 7512847
  33. Identification of novel sequences and codon usage in Strongyloides stercoralis.
    Mol Biochem Parasitol. 1996 Aug;79(2):243-8 PMID: 8855562
  34. The neurons of class ALD mediate thermotaxis in the parasitic nematode, Strongyloides stercoralis.
    Int J Parasitol. 2000 Sep;30(10):1115-21 PMID: 10996330
  35. Duodenal strongyloides stercoralis infection.
    Endoscopy. 1994 Feb;26(2):272 PMID: 8026386
  36. Molecular phylogenetic analysis of the genus Strongyloides and related nematodes.
    Int J Parasitol. 2002 Nov;32(12):1507-17 PMID: 12392916
  37. A molecular evolutionary framework for the phylum Nematoda.
    Nature. 1998 Mar 5;392(6671):71-5 PMID: 9510248
  38. Database resources of the National Center for Biotechnology Information.
    Nucleic Acids Res. 2001 Jan 1;29(1):11-6 PMID: 11125038
  39. Parasitic helminth genomics. Filarial Genome Project.
    Parasitology. 1999;118 Suppl:S39-51 PMID: 10466136
  40. Ingestion of double-stranded RNA by preparasitic juvenile cyst nematodes leads to RNA interference.
    Mol Plant Microbe Interact. 2002 Aug;15(8):747-52 PMID: 12182331
  41. InterProScan--an integration platform for the signature-recognition methods in InterPro.
    Bioinformatics. 2001 Sep;17(9):847-8 PMID: 11590104
  42. Expression of the microfilarial sheath protein 2 (shp2) of the filarial parasites Litomosoides sigmodontis and Brugia malayi.
    Exp Parasitol. 1997 Mar;85(3):241-8 PMID: 9085921
  43. The InterPro database, an integrated documentation resource for protein families, domains and functional sites.
    Nucleic Acids Res. 2001 Jan 1;29(1):37-40 PMID: 11125043
  44. Experimental disseminated strongyloidiasis in Erythrocebus patas. I. Pathology.
    Am J Trop Med Hyg. 1984 May;33(3):431-43 PMID: 6731675
  45. Identification, synthesis and immunogenicity of cuticular collagens from the filarial nematodes Brugia malayi and Brugia pahangi.
    Mol Biochem Parasitol. 1989 Jan 15;32(2-3):229-46 PMID: 2927447
  46. Basic local alignment search tool.
    J Mol Biol. 1990 Oct 5;215(3):403-10 PMID: 2231712
  47. PCR amplification of putative gpa-2 and gpa-3 orthologs from the (A+T)-rich genome of Strongyloides stercoralis.
    Int J Parasitol. 2001 Apr;31(4):377-83 PMID: 11306115
  48. Genomic analysis of gene expression in C. elegans.
    Science. 2000 Oct 27;290(5492):809-12 PMID: 11052945
  49. A cDNA encoding the highly immunodominant antigen of Strongyloides stercoralis: gamma-subunit of isocitrate dehydrogenase (NAD+).
    Parasitol Res. 2000 Apr;86(4):279-83 PMID: 10780735
  50. The Caenorhabditis elegans muscle-affecting gene unc-87 encodes a novel thin filament-associated protein.
    J Cell Biol. 1994 Oct;127(1):79-93 PMID: 7929573
  51. Strongyloides stercoralis: identification of antigens in natural human infections from endemic areas of the United States.
    Parasitol Res. 1997;83(7):655-8 PMID: 9272553
  52. Suppression of secreted acetylcholinesterase expression in Nippostrongylus brasiliensis by RNA interference.
    Mol Biochem Parasitol. 2002 Jun;122(1):91-4 PMID: 12076773
  53. Oxidative stress and ageing in Caenorhabditis elegans.
    Biochem J. 1993 Jun 1;292 ( Pt 2):605-8 PMID: 8389142
  54. Evaluation of a recombinant parasite antigen for the diagnosis of lymphatic filariasis.
    Am J Trop Med Hyg. 1994 Jun;50(6):727-34 PMID: 8024066
  55. Large-scale analysis of gene function in Caenorhabditis elegans by high-throughput RNAi.
    Curr Biol. 2001 Feb 6;11(3):171-6 PMID: 11231151
  56. Changes in gene expression associated with developmental arrest and longevity in Caenorhabditis elegans.
    Genome Res. 2001 Aug;11(8):1346-52 PMID: 11483575
  57. Mutations that perturb vulval invagination in C. elegans.
    Cold Spring Harb Symp Quant Biol. 1997;62:353-9 PMID: 9598369
  58. Post-genomic nematode parasitology.
    Int J Parasitol. 2001 Jul;31(9):879-88 PMID: 11406137
  59. Molecular cloning and characterisation of a venom allergen AG5-like cDNA from Meloidogyne incognita.
    Int J Parasitol. 2000 Jan;30(1):77-81 PMID: 10675748
  60. Molecular and genetic analyses of the Caenorhabditis elegans dpy-2 and dpy-10 collagen genes: a variety of molecular alterations affect organismal morphology.
    Mol Biol Cell. 1993 Aug;4(8):803-17 PMID: 8241567
  61. cDNA cloning of porcine brain prolyl endopeptidase and identification of the active-site seryl residue.
    Biochemistry. 1991 Feb 26;30(8):2195-203 PMID: 1900195
  62. Functional genomic analysis of C. elegans chromosome I by systematic RNA interference.
    Nature. 2000 Nov 16;408(6810):325-30 PMID: 11099033
  63. A hookworm allergen which strongly resembles calreticulin.
    Parasite Immunol. 1999 Sep;21(9):439-50 PMID: 10476053
  64. The Brugia malayi genome project: expressed sequence tags and gene discovery.
    Trans R Soc Trop Med Hyg. 2002 Jan-Feb;96(1):7-17 PMID: 11925998
  65. The TIGR Gene Indices: analysis of gene transcript sequences in highly sampled eukaryotic species.
    Nucleic Acids Res. 2001 Jan 1;29(1):159-64 PMID: 11125077
  66. Molecular and biochemical aspects of nematode collagens.
    J Parasitol. 1992 Feb;78(1):1-15 PMID: 1738051
  67. Epitopes of the Onchocerca volvulus RAL1 antigen, a member of the calreticulin family of proteins, recognized by sera from patients with onchocerciasis.
    Infect Immun. 1994 Sep;62(9):3696-704 PMID: 7520419
  68. The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development.
    Nature. 1993 Oct 14;365(6447):644-9 PMID: 8413626
  69. Cuticular proteins of Brugia filarial parasites.
    Acta Trop. 1990 Jul;47(5-6):373-80 PMID: 1978537
  70. Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III.
    Nature. 2000 Nov 16;408(6810):331-6 PMID: 11099034
  71. Genes and genomes of Necator americanus and related hookworms.
    Int J Parasitol. 2000 Apr 10;30(4):347-55 PMID: 10731559
  72. Analysis and functional classification of transcripts from the nematode Meloidogyne incognita.
    Genome Biol. 2003;4(4):R26 PMID: 12702207
  73. Nematode gene sequences, update for june 2002.
    J Nematol. 2002 Jun;34(2):71-4 PMID: 19265911
  74. Genes that regulate both development and longevity in Caenorhabditis elegans.
    Genetics. 1995 Apr;139(4):1567-83 PMID: 7789761
  75. New members of the collagen superfamily.
    Curr Opin Cell Biol. 1993 Oct;5(5):883-90 PMID: 8240831
  76. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium.
    Nat Genet. 2000 May;25(1):25-9 PMID: 10802651
  77. sqv mutants of Caenorhabditis elegans are defective in vulval epithelial invagination.
    Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):968-73 PMID: 9927677
  78. Exploiting the life cycle of Strongyloides ratii.
    Parasitol Today. 1999 Jun;15(6):231-5 PMID: 10366829
  79. Base-calling of automated sequencer traces using phred. I. Accuracy assessment.
    Genome Res. 1998 Mar;8(3):175-85 PMID: 9521921
  80. The significance of digital gene expression profiles.
    Genome Res. 1997 Oct;7(10):986-95 PMID: 9331369
  81. Systematic functional analysis of the Caenorhabditis elegans genome using RNAi.
    Nature. 2003 Jan 16;421(6920):231-7 PMID: 12529635
Article Info
Journal
Genome research
Abbr.
Genome Res
ISSN
1088-9051
DOI
10.1101/gr.1524804
Email
mmitreva@watson.wstl.edu
Published
2004-02-00
Pages
209-20
Language
English
Region
United States
NLM ID
9518021
PMCID
PMC327096
Subset
IM
Grants
NIAID NIH HHS · U01 AI046593 · United States
NIAID NIH HHS · AI46593 · United States
Databases
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AW496199, AW496200, AW496201, AW496202, AW496203, AW496204, AW496205, AW496206, AW496207, AW496208, AW496209, AW496210, AW496211, AW496212, AW496213, AW496214, AW496215, AW496216, AW496217, AW496218, AW496219, AW496220, AW496221, AW496222, AW496223, AW496224, AW496225, AW496226, AW496227, AW496228, AW496229, AW496230, AW496231, AW496232, AW496233, AW496234, AW496235, AW496236, AW496237, AW496238, AW496239, AW496240, AW496241, AW496242, AW496243, AW496244, AW496245, AW496246, AW496247, AW496248, AW496249, AW496250, AW496251, AW496252, AW496253, AW496254, AW496255, AW496256, AW496257, AW496258, AW496259, AW496260, AW496261, AW496262, AW496263, AW496264, AW496265, AW496266, AW496267, AW496268, AW496269, AW496270, AW496271, AW496272, AW496273, AW496274, AW496275, AW496276, AW496277, AW496278, AW496279, AW496280, AW496281, AW496282, AW496283, AW496284, AW496285, AW496286, AW496287, AW496288, AW496289, AW496290, AW496291, AW496292, AW496293, AW496294, AW496295, AW496296, AW496297, AW496298, 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AW496399, AW496400, AW496401, AW496402, AW496403, AW496404, AW496405, AW496406, AW496407, AW496408, AW496409, AW496410, AW496411, AW496412, AW496413, AW496414, AW496415, AW496416, AW496417, AW496418, AW496419, AW496420, AW496421, AW496422, AW496423, AW496424, AW496425, AW496426, AW496427, AW496428, AW496429, AW496430, AW496431, AW496432, AW496433, AW496434, AW496435, AW496436, AW496437, AW496438, AW496439, AW496440, AW496441, AW496442, AW496443, AW496444, AW496445, AW496446, AW496447, AW496448, AW496449, AW496450, AW496451, AW496452, AW496453, AW496454, AW496455, AW496456, AW496457, AW496458, AW496459, AW496460, AW496461, AW496462, AW496463, AW496464, AW496465, AW496466, AW496467, AW496468, AW496469, AW496470, AW496471, AW496472, AW496473, AW496474, AW496475, AW496476, AW496477, AW496478, AW496479, AW496480, AW496481, AW496482, AW496483, AW496484, AW496485, AW496486, AW496487, AW496488, AW496489, AW496490, AW496491, AW496492, AW496493, AW496494, AW496495, AW496496, AW496497, AW496498
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PubMed source DOI: 10.1101/gr.1524804 PMC Full Text View journal details
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