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PMID: 11557892 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

A gene expression map for Caenorhabditis elegans.

Science (New York, N.Y.) ·Vol. 293 ·No. 5537 ·2001-09-14 ·Pages 2087-92

Kim SK, Lund J, Kiraly M, Duke K, Jiang M, Stuart JM, Eizinger A, Wylie BN, Davidson GS

Abstract

We have assembled data from Caenorhabditis elegans DNA microarray experiments involving many growth conditions, developmental stages, and varieties of mutants. Co-regulated genes were grouped together and visualized in a three-dimensional expression map that displays correlations of gene expression profiles as distances in two dimensions and gene density in the third dimension. The gene expression map can be used as a gene discovery tool to identify genes that are co-regulated with known sets of genes (such as heat shock, growth control genes, germ line genes, and so forth) or to uncover previously unknown genetic functions (such as genomic instability in males and sperm caused by specific transposons).

MeSH Terms

Algorithms Animals Caenorhabditis elegans/genetics,physiology Computational Biology DNA Transposable Elements DNA, Complementary Databases, Factual Female Gene Expression Gene Expression Profiling Gene Expression Regulation Genes, Helminth Genome Genomics Helminth Proteins/biosynthesis,genetics Intestines/physiology Male Muscles/physiology Neurons/physiology Nucleic Acid Hybridization Oligonucleotide Array Sequence Analysis Oocytes/physiology RNA, Helminth/genetics Software Spermatozoa/physiology

Chemicals

DNA Transposable Elements DNA, Complementary Helminth Proteins RNA, Helminth

Authors & Affiliations

9 authors, click to expand affiliations / ORCID

Kim S K

Department of Developmental Biology and Genetics, Stanford University Medical School, Stanford, CA 94305, USA. kim@cmgm.stanford.edu

Lund J

Kiraly M

Duke K

Jiang M

Stuart J M

Eizinger A

Wylie B N

Davidson G S

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.1061603

kim@cmgm.stanford.edu

Published

2001-09-14

Pages

2087-92

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.1061603 View journal details

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