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PMID: 14759262 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Versatile and open software for comparing large genomes.

Genome biology ·Vol. 5 ·No. 2 ·2004-00-00 ·Pages R12

Kurtz S, Phillippy A, Delcher AL, Smoot M, Shumway M, Antonescu C, Salzberg SL

Abstract

The newest version of MUMmer easily handles comparisons of large eukaryotic genomes at varying evolutionary distances, as demonstrated by applications to multiple genomes. Two new graphical viewing tools provide alternative ways to analyze genome alignments. The new system is the first version of MUMmer to be released as open-source software. This allows other developers to contribute to the code base and freely redistribute the code. The MUMmer sources are available at http://www.tigr.org/software/mummer.

MeSH Terms
Animals Anopheles/genetics Computer Graphics Drosophila/genetics Genome Genome, Fungal Genome, Human Genomics/methods Humans Sequence Alignment/methods Software
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Kurtz Stefan
Center for Bioinformatics, University of Hamburg, Bundesstrasse 43, 20146 Hamburg, Germany.
Phillippy Adam
Delcher Arthur L
Smoot Michael
Shumway Martin
Antonescu Corina
Salzberg Steven L
References (28)
28 references, click to expand
  1. Flexible sequence similarity searching with the FASTA3 program package.
    Methods Mol Biol. 2000;132:185-219 PMID: 10547837
  2. CAP3: A DNA sequence assembly program.
    Genome Res. 1999 Sep;9(9):868-77 PMID: 10508846
  3. SSAHA: a fast search method for large DNA databases.
    Genome Res. 2001 Oct;11(10):1725-9 PMID: 11591649
  4. REPuter: the manifold applications of repeat analysis on a genomic scale.
    Nucleic Acids Res. 2001 Nov 15;29(22):4633-42 PMID: 11713313
  5. ARACHNE: a whole-genome shotgun assembler.
    Genome Res. 2002 Jan;12(1):177-89 PMID: 11779843
  6. Fast algorithms for large-scale genome alignment and comparison.
    Nucleic Acids Res. 2002 Jun 1;30(11):2478-83 PMID: 12034836
  7. Comparative genome sequencing for discovery of novel polymorphisms in Bacillus anthracis.
    Science. 2002 Jun 14;296(5575):2028-33 PMID: 12004073
  8. Efficient multiple genome alignment.
    Bioinformatics. 2002;18 Suppl 1:S312-20 PMID: 12169561
  9. Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.
    J Bacteriol. 2002 Oct;184(19):5479-90 PMID: 12218036
  10. Comparative genome and proteome analysis of Anopheles gambiae and Drosophila melanogaster.
    Science. 2002 Oct 4;298(5591):149-59 PMID: 12364792
  11. Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii.
    Nature. 2002 Oct 3;419(6906):512-9 PMID: 12368865
  12. Initial sequencing and comparative analysis of the mouse genome.
    Nature. 2002 Dec 5;420(6915):520-62 PMID: 12466850
  13. The phusion assembler.
    Genome Res. 2003 Jan;13(1):81-90 PMID: 12529309
  14. AVID: A global alignment program.
    Genome Res. 2003 Jan;13(1):97-102 PMID: 12529311
  15. Human-mouse alignments with BLASTZ.
    Genome Res. 2003 Jan;13(1):103-7 PMID: 12529312
  16. LAGAN and Multi-LAGAN: efficient tools for large-scale multiple alignment of genomic DNA.
    Genome Res. 2003 Apr;13(4):721-31 PMID: 12654723
  17. The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria.
    Nature. 2003 May 1;423(6935):81-6 PMID: 12721629
  18. An applications-focused review of comparative genomics tools: capabilities, limitations and future challenges.
    Brief Bioinform. 2003 Jun;4(2):105-23 PMID: 12846393
  19. Identification of common molecular subsequences.
    J Mol Biol. 1981 Mar 25;147(1):195-7 PMID: 7265238
  20. Efficient algorithms for folding and comparing nucleic acid sequences.
    Nucleic Acids Res. 1982 Jan 11;10(1):197-206 PMID: 6174935
  21. Improved tools for biological sequence comparison.
    Proc Natl Acad Sci U S A. 1988 Apr;85(8):2444-8 PMID: 3162770
  22. Basic local alignment search tool.
    J Mol Biol. 1990 Oct 5;215(3):403-10 PMID: 2231712
  23. The complete genome sequence of the gastric pathogen Helicobacter pylori.
    Nature. 1997 Aug 7;388(6642):539-47 PMID: 9252185
  24. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.
    Nucleic Acids Res. 1997 Sep 1;25(17):3389-402 PMID: 9254694
  25. Consed: a graphical tool for sequence finishing.
    Genome Res. 1998 Mar;8(3):195-202 PMID: 9521923
  26. Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori.
    Nature. 1999 Jan 14;397(6715):176-80 PMID: 9923682
  27. Alignment of whole genomes.
    Nucleic Acids Res. 1999 Jun 1;27(11):2369-76 PMID: 10325427
  28. A whole-genome assembly of Drosophila.
    Science. 2000 Mar 24;287(5461):2196-204 PMID: 10731133
Article Info
Journal
Genome biology
Abbr.
Genome Biol
ISSN
1474-760X
Published
2004-00-00
Epub
2004-00-30
Pages
R12
Language
English
Region
England
NLM ID
100960660
PMCID
PMC395750
Subset
IM
Grants
NIGMS NIH HHS · T32 GM008715 · United States
NLM NIH HHS · R01 LM006845 · United States
NIGMS NIH HHS · T32 GM08715 · United States
NIAID NIH HHS · N01AI15447 · United States
NLM NIH HHS · R01-LM06845 · United States
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