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PMID: 14758088 Published · ppublish English Journal Article Review

Galectins in kidney development.

Glycoconjugate journal ·Vol. 19 ·No. 7-9 ·2002-00-00 ·Pages 621-9

Hughes RC

Abstract

Galectins are a family of proteins with overlapping but distinct carbohydrate-binding specificities. They differ in cell-type and tissue distribution, and have various functions. Extracellularly several galectins can modulate cellular adhesive interactions and signalling pathways, effects that may be important in the establishment and maintenance of tissue organization during normal development. This review will summarise recent progress in defining the roles of galectins that are expressed in the kidney in normal development, and discuss the evidence linking aberrant expression of galectins with kidney disease.

MeSH Terms
Animals Cell Differentiation Galectins/metabolism Humans Kidney/cytology,embryology,growth & development,metabolism Kidney Diseases/metabolism,pathology Signal Transduction
Chemicals
Galectins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Hughes R Colin
National Institute for Medical Research, Mill Hill, London NW7 1AA, UK. colin.hughes@nimr.mrc.ac.uk
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Article Info
Journal
Glycoconjugate journal
Abbr.
Glycoconj J
ISSN
0282-0080
DOI
10.1023/B:GLYC.0000014094.39168.fd
Email
colin.hughes@nimr.mrc.ac.uk
Published
2002-00-00
Pages
621-9
Language
English
Region
United States
NLM ID
8603310
Subset
IM
External Links
PubMed source DOI: 10.1023/B:GLYC.0000014094.39168.fd View journal details
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