Home LiteratureArticle Details
PMID: 14681457 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

MitoP2, an integrated database on mitochondrial proteins in yeast and man.

Nucleic acids research ·Vol. 32 ·No. Database issue ·2004-01-01 ·Pages D459-62

Andreoli C, Prokisch H, Hörtnagel K, Mueller JC, Münsterkötter M, Scharfe C, Meitinger T

Abstract

The aim of the MitoP2 database (http://ihg.gsf.de/mitop2) is to provide a comprehensive list of mitochondrial proteins of yeast and man. Based on the current literature we created an annotated reference set of yeast and human proteins. In addition, data sets relevant to the study of the mitochondrial proteome are integrated and accessible via search tools and links. They include computational predictions of signalling sequences, and summarize results from proteome mapping, mutant screening, expression profiling, protein-protein interaction and cellular sublocalization studies. For each individual approach, specificity and sensitivity for allocating mitochondrial proteins was calculated. By providing the evidence for mitochondrial candidate proteins the MitoP2 database lends itself to the genetic characterization of human mitochondriopathies.

MeSH Terms
Computational Biology Databases, Genetic Humans Information Storage and Retrieval Internet Mitochondrial Proteins/genetics,metabolism Mutation Protein Binding Proteome Saccharomyces cerevisiae Proteins/genetics,metabolism
Chemicals
Mitochondrial Proteins Proteome Saccharomyces cerevisiae Proteins
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Andreoli C
Institute of Human Genetics, GSF National Research Center for Environment and Health, Neuherberg, Germany.
Prokisch H
Hörtnagel K
Mueller J C
Münsterkötter M
Scharfe C
Meitinger T
References (26)
26 references, click to expand
  1. PSORT: a program for detecting sorting signals in proteins and predicting their subcellular localization.
    Trends Biochem Sci. 1999 Jan;24(1):34-6 PMID: 10087920
  2. MITOMAP: a human mitochondrial genome database--1998 update.
    Nucleic Acids Res. 1998 Jan 1;26(1):112-5 PMID: 9399813
  3. Nuclear power and mitochondrial disease.
    Nat Genet. 1998 Jul;19(3):214-5 PMID: 9662387
  4. MitBASE : a comprehensive and integrated mitochondrial DNA database. The present status.
    Nucleic Acids Res. 2000 Jan 1;28(1):148-52 PMID: 10592207
  5. MITOP, the mitochondrial proteome database: 2000 update.
    Nucleic Acids Res. 2000 Jan 1;28(1):155-8 PMID: 10592209
  6. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium.
    Nat Genet. 2000 May;25(1):25-9 PMID: 10802651
  7. A Bayesian system integrating expression data with sequence patterns for localizing proteins: comprehensive application to the yeast genome.
    J Mol Biol. 2000 Aug 25;301(4):1059-75 PMID: 10966805
  8. Mitochondria make a come back.
    Adv Drug Deliv Rev. 2001 Jul 2;49(1-2):3-26 PMID: 11377800
  9. Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.
    Nature. 2001 Nov 22;414(6862):450-3 PMID: 11719806
  10. MIPS: a database for genomes and protein sequences.
    Nucleic Acids Res. 2002 Jan 1;30(1):31-4 PMID: 11752246
  11. Saccharomyces Genome Database (SGD) provides secondary gene annotation using the Gene Ontology (GO).
    Nucleic Acids Res. 2002 Jan 1;30(1):69-72 PMID: 11752257
  12. The TRIPLES database: a community resource for yeast molecular biology.
    Nucleic Acids Res. 2002 Jan 1;30(1):73-5 PMID: 11752258
  13. Genome-wide analysis of mRNAs targeted to yeast mitochondria.
    EMBO Rep. 2002 Feb;3(2):159-64 PMID: 11818335
  14. Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae.
    Mol Biol Cell. 2002 Mar;13(3):847-53 PMID: 11907266
  15. Comparative assessment of large-scale data sets of protein-protein interactions.
    Nature. 2002 May 23;417(6887):399-403 PMID: 12000970
  16. Systematic identification of mitochondrial proteins by LC-MS/MS.
    Anal Chem. 2002 May 15;74(10):2400-6 PMID: 12038767
  17. Systematic screen for human disease genes in yeast.
    Nat Genet. 2002 Aug;31(4):400-4 PMID: 12134146
  18. Modeling the percolation of annotation errors in a database of protein sequences.
    Bioinformatics. 2002 Dec;18(12):1641-9 PMID: 12490449
  19. The SWISS-PROT protein knowledgebase and its supplement TrEMBL in 2003.
    Nucleic Acids Res. 2003 Jan 1;31(1):365-70 PMID: 12520024
  20. Hap4p overexpression in glucose-grown Saccharomyces cerevisiae induces cells to enter a novel metabolic state.
    Genome Biol. 2003;4(1):R3 PMID: 12537548
  21. Characterization of the human heart mitochondrial proteome.
    Nat Biotechnol. 2003 Mar;21(3):281-6 PMID: 12592411
  22. Nuclear genes in mitochondrial disorders.
    Curr Opin Genet Dev. 2003 Jun;13(3):262-70 PMID: 12787788
  23. PET genes of Saccharomyces cerevisiae.
    Microbiol Rev. 1990 Sep;54(3):211-25 PMID: 2215420
  24. MitoProt, a Macintosh application for studying mitochondrial proteins.
    Comput Appl Biosci. 1995 Aug;11(4):441-7 PMID: 8521054
  25. Exploring the metabolic and genetic control of gene expression on a genomic scale.
    Science. 1997 Oct 24;278(5338):680-6 PMID: 9381177
  26. Protein import into mitochondria.
    Annu Rev Biochem. 1997;66:863-917 PMID: 9242927
Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
1362-4962
DOI
10.1093/nar/gkh137
Published
2004-01-01
Pages
D459-62
Language
English
Region
England
NLM ID
0411011
PMCID
PMC308871
Subset
IM
External Links
PubMed source DOI: 10.1093/nar/gkh137 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2