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PMID: 14660736 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Quorum sensing and biofilm formation in Streptococcal infections.

The Journal of clinical investigation ·Vol. 112 ·No. 11 ·2003-12-00 ·Pages 1626-32

Cvitkovitch DG, Li YH, Ellen RP

Abstract

Members of the bacterial genus Streptococcus are responsible for causing a wide variety of infections in humans. Many Streptococci use quorum-sensing systems to regulate several physiological properties, including the ability to incorporate foreign DNA, tolerate acid, form biofilms, and become virulent. These quorum-sensing systems are primarily made of small soluble signal peptides that are detected by neighboring cells via a histidine kinase/response regulator pair.

MeSH Terms
Bacterial Proteins/physiology Bacteriocins/pharmacology Biofilms Dental Plaque/microbiology Hydrogen-Ion Concentration Signal Transduction Streptococcal Infections/etiology Streptococcus/pathogenicity,physiology
Chemicals
Bacterial Proteins Bacteriocins competence factor, Streptococcus
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Cvitkovitch Dennis G
Room 449A, Dental Research Institute, University of Toronto, 124 Edward Street, Toronto, Ontario M5G 1G6, Canada. dennis.cvitkovitch@utoronto.ca
Li Yung-Hua
Ellen Richard P
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI20430
Email
dennis.cvitkovitch@utoronto.ca
Published
2003-12-00
Pages
1626-32
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC281653
Subset
IM
External Links
PubMed source DOI: 10.1172/JCI20430 PMC Full Text View journal details
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