Home LiteratureArticle Details
PMID: 14557668 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Hendra virus V protein inhibits interferon signaling by preventing STAT1 and STAT2 nuclear accumulation.

Journal of virology ·Vol. 77 ·No. 21 ·2003-11-00 ·Pages 11842-5

Rodriguez JJ, Wang LF, Horvath CM

Abstract

The V protein of the recently emerged paramyxovirus, Nipah virus, has been shown to inhibit interferon (IFN) signal transduction through cytoplasmic sequestration of cellular STAT1 and STAT2 in high-molecular-weight complexes. Here we demonstrate that the closely related Hendra virus V protein also inhibits cellular responses to IFN through binding and cytoplasmic sequestration of both STAT1 and STAT2, but not STAT3. These findings demonstrate a V protein-mediated IFN signal evasion mechanism that is a general property of the known Henipavirus species.

MeSH Terms
Amino Acid Sequence Cell Line Cell Nucleus/metabolism DNA-Binding Proteins/metabolism Humans Interferon-alpha/metabolism Interferon-gamma/metabolism Molecular Sequence Data STAT1 Transcription Factor STAT2 Transcription Factor Signal Transduction/drug effects Trans-Activators/metabolism Viral Proteins/metabolism,pharmacology
Chemicals
DNA-Binding Proteins Interferon-alpha STAT1 Transcription Factor STAT1 protein, human STAT2 Transcription Factor STAT2 protein, human Trans-Activators V protein, Hendra virus Viral Proteins Interferon-gamma
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Rodriguez Jason J
Immunobiology Center, Mount Sinai School of Medicine, New York, New York 10029, USA.
Wang Lin-Fa
Horvath Curt M
References (19)
19 references, click to expand
  1. RING domains: master builders of molecular scaffolds?
    J Mol Biol. 2000 Feb 4;295(5):1103-12 PMID: 10653689
  2. The V protein of simian virus 5 inhibits interferon signalling by targeting STAT1 for proteasome-mediated degradation.
    J Virol. 1999 Dec;73(12):9928-33 PMID: 10559305
  3. Nipah virus: a recently emergent deadly paramyxovirus.
    Science. 2000 May 26;288(5470):1432-5 PMID: 10827955
  4. Solution structure of the PHD domain from the KAP-1 corepressor: structural determinants for PHD, RING and LIM zinc-binding domains.
    EMBO J. 2001 Jan 15;20(1-2):165-77 PMID: 11226167
  5. Molecular biology of Hendra and Nipah viruses.
    Microbes Infect. 2001 Apr;3(4):279-87 PMID: 11334745
  6. The natural history of Hendra and Nipah viruses.
    Microbes Infect. 2001 Apr;3(4):307-14 PMID: 11334748
  7. The V protein of human parainfluenza virus 2 antagonizes type I interferon responses by destabilizing signal transducer and activator of transcription 2.
    Virology. 2001 May 10;283(2):230-9 PMID: 11336548
  8. Nipah virus infection in bats (order Chiroptera) in peninsular Malaysia.
    Emerg Infect Dis. 2001 May-Jun;7(3):439-41 PMID: 11384522
  9. The paramyxovirus SV5 V protein binds two atoms of zinc and is a structural component of virions.
    Virology. 1995 Apr 1;208(1):121-31 PMID: 11831692
  10. Nipah virus V protein evades alpha and gamma interferons by preventing STAT1 and STAT2 activation and nuclear accumulation.
    J Virol. 2002 Nov;76(22):11476-83 PMID: 12388709
  11. C-terminal region of STAT-1alpha is not necessary for its ubiquitination and degradation caused by mumps virus V protein.
    J Virol. 2002 Dec;76(24):12683-90 PMID: 12438594
  12. Newcastle disease virus (NDV)-based assay demonstrates interferon-antagonist activity for the NDV V protein and the Nipah virus V, W, and C proteins.
    J Virol. 2003 Jan;77(2):1501-11 PMID: 12502864
  13. Paramyxoviruses SV5 and HPIV2 assemble STAT protein ubiquitin ligase complexes from cellular components.
    Virology. 2002 Dec 20;304(2):160-6 PMID: 12504558
  14. STAT3 ubiquitylation and degradation by mumps virus suppress cytokine and oncogene signaling.
    J Virol. 2003 Jun;77(11):6385-93 PMID: 12743296
  15. STAT protein interference and suppression of cytokine signal transduction by measles virus V protein.
    J Virol. 2003 Jul;77(13):7635-44 PMID: 12805463
  16. Two mRNAs that differ by two nontemplated nucleotides encode the amino coterminal proteins P and V of the paramyxovirus SV5.
    Cell. 1988 Sep 9;54(6):891-902 PMID: 3044614
  17. A morbillivirus that caused fatal disease in horses and humans.
    Science. 1995 Apr 7;268(5207):94-7 PMID: 7701348
  18. A novel P/V/C gene in a new member of the Paramyxoviridae family, which causes lethal infection in humans, horses, and other animals.
    J Virol. 1998 Feb;72(2):1482-90 PMID: 9445051
  19. Paramyxoviridae use distinct virus-specific mechanisms to circumvent the interferon response.
    Virology. 2000 Apr 10;269(2):383-90 PMID: 10753717
Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/jvi.77.21.11842-11845.2003
Published
2003-11-00
Pages
11842-5
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC229371
Subset
IM
Grants
NIAID NIH HHS · R01 AI048722 · United States
NIAID NIH HHS · AI-50707 · United States
NIGMS NIH HHS · T32 GM062754 · United States
NIAID NIH HHS · AI-48722 · United States
NIAID NIH HHS · R21 AI048722 · United States
NIAID NIH HHS · R01 AI050707 · United States
NIGMS NIH HHS · GM-62754 · United States
Corrections
ErratumIn
-
External Links
PubMed source DOI: 10.1128/jvi.77.21.11842-11845.2003 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2