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PMID: 14502271 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Macrophage migration inhibitory factor: a regulator of innate immunity.

Nature reviews. Immunology ·Vol. 3 ·No. 10 ·2003-10-00 ·Pages 791-800

Calandra T, Roger T

Abstract

For more than a quarter of a century, macrophage migration inhibitory factor (MIF) has been a mysterious cytokine. In recent years, MIF has assumed an important role as a pivotal regulator of innate immunity. MIF is an integral component of the host antimicrobial alarm system and stress response that promotes the pro-inflammatory functions of immune cells. A rapidly increasing amount of literature indicates that MIF is implicated in the pathogenesis of sepsis, and inflammatory and autoimmune diseases, suggesting that MIF-directed therapies might offer new treatment opportunities for human diseases in the future.

MeSH Terms
Animals Autoimmune Diseases/etiology,immunology Humans Immunity, Innate/genetics,immunology Inflammation/etiology,immunology Macrophage Migration-Inhibitory Factors/genetics,immunology Macrophages/immunology Sepsis/etiology,immunology
Chemicals
Macrophage Migration-Inhibitory Factors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Calandra Thierry
Division of Infectious Diseases, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, CH-1011 Lausanne, Switzerland. Thierry.Calandra@hospvd.ch
Roger Thierry
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Article Info
Journal
Nature reviews. Immunology
Abbr.
Nat Rev Immunol
ISSN
1474-1733
DOI
10.1038/nri1200
Email
thierry.calandra@hospvd.ch
Published
2003-10-00
Pages
791-800
Language
English
Region
England
NLM ID
101124169
PMCID
PMC7097468
Subset
IM
External Links
PubMed source DOI: 10.1038/nri1200 PMC Full Text View journal details
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