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PMID: 9395080 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The macrophage migration inhibitory factor MIF is a phenylpyruvate tautomerase.

FEBS letters ·Vol. 417 ·No. 1 ·1997-11-03 ·Pages 85-8

Rosengren E, Aman P, Thelin S, Hansson C, Ahlfors S, Björk P, Jacobsson L, Rorsman H

Abstract

A macrophage migration inhibitory factor (MIF), originally described as a product of activated lymphocytes, has been defined as a 12 kDa protein, expressed in a wide variety of tissues. Here MIF is identified as a phenylpyruvate tautomerase (EC 5.3.2.1) having p-hydroxyphenylpyruvate and phenylpyruvate as its natural substrates. The definition of MIF as an enzyme may yield insight into the mechanism of action of this proinflammatory and immunomodulating cytokine.

MeSH Terms
Amino Acids/analysis Animals Cattle Humans Indolequinones Indoles/metabolism Intramolecular Oxidoreductases/chemistry,metabolism,pharmacology Macrophage Migration-Inhibitory Factors/chemistry,metabolism,pharmacology Phenylpyruvic Acids/metabolism Quinones/metabolism Recombinant Fusion Proteins/chemistry,metabolism,pharmacology Substrate Specificity
Chemicals
Amino Acids Indolequinones Indoles Macrophage Migration-Inhibitory Factors Phenylpyruvic Acids Quinones Recombinant Fusion Proteins 4-hydroxyphenylpyruvic acid dopachrome 5,6-dihydroxy-2-indolylcarboxylic acid Intramolecular Oxidoreductases phenylpyruvate tautomerase phenylpyruvic acid
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Rosengren E
Department of Pharmacology, University of Lund, Sweden.
Aman P
Thelin S
Hansson C
Ahlfors S
Björk P
Jacobsson L
Rorsman H
Article Info
Journal
FEBS letters
Abbr.
FEBS Lett
ISSN
0014-5793
DOI
10.1016/s0014-5793(97)01261-1
Published
1997-11-03
Pages
85-8
Language
English
Region
England
NLM ID
0155157
Subset
IM
External Links
PubMed source DOI: 10.1016/s0014-5793(97)01261-1 View journal details
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