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PMID: 14453768 Published · ppublish English Journal Article

Inhibition of red cell sequestration by cortisone.

The Journal of experimental medicine ·Vol. 114 ·1961-12-01 ·Pages 921-37

KAPLAN ME, JANDL JH

Abstract

The effect of cortisone on the sequestration of (a) antibody-coated red cells and (b) incubated red cells was studied in rats. Cortisone administration inhibited the hepatic sequestration of red cells altered by non-immune as well as by immune injury. There was a latent period of 2 days between the institution of cortisone therapy and its first manifest effect on hepatic sequestration. The splenic sequestration of altered red cells was not inhibited by cortisone, and there was no inhibition of the sequestration of hemoglobin by either liver or spleen. It is suggested that steroids may inhibit hepatic sequestration through hemodynamic effects.

Keywords
CORTISONE/pharmacology ERYTHROCYTES/pharmacology
MeSH Terms
Animals Antibodies Cortisone/pharmacology Erythrocytes/pharmacology Liver Rats Spleen
Chemicals
Antibodies Cortisone
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
KAPLAN M E
JANDL J H
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54 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.114.6.921
Published
1961-12-01
Pages
921-37
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2180402
Subset
OM
External Links
PubMed source DOI: 10.1084/jem.114.6.921 PMC Full Text View journal details
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