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PMID: 1444316 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Bactericidal activity of ramoplanin against antibiotic-resistant enterococci.

Antimicrobial agents and chemotherapy ·Vol. 36 ·No. 10 ·1992-10-00 ·Pages 2342-5

Johnson CC, Taylor S, Pitsakis P, May P, Levison ME

Abstract

Ramoplanin, a new lipoglycodepsipeptide antibiotic, was uniformly active against 65 strains of enterococci, including strains highly resistant to vancomycin, penicillin G, and gentamicin. MBCs were usually within a fourfold dilution of the MICs. In time-kill studies, ramoplanin alone demonstrated dose-dependent bactericidal activity against enterococcal strains that resisted killing by vancomycin or penicillin in combination with gentamicin.

MeSH Terms
Anti-Bacterial Agents/pharmacology Depsipeptides Drug Resistance, Microbial Enterococcus/drug effects Microbial Sensitivity Tests Peptides, Cyclic
Chemicals
Anti-Bacterial Agents Depsipeptides Peptides, Cyclic ramoplanin
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Johnson C C
Medical College of Pennsylvania, Philadelphia 19129.
Taylor S
Pitsakis P
May P
Levison M E
References (21)
21 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.36.10.2342
Published
1992-10-00
Pages
2342-5
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC245501
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.36.10.2342 PMC Full Text View journal details
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