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PMID: 1826593 Published · ppublish English Journal Article

In vitro activities of ramoplanin and four glycopeptide antibiotics against clinical isolates of Clostridium difficile.

Antimicrobial agents and chemotherapy ·Vol. 35 ·No. 1 ·1991-01-00 ·Pages 195-7

Biavasco F, Manso E, Varaldo PE

Abstract

Seventy strains of Clostridium difficile, all isolated from symptomatic patients, were found to be uniformly susceptible to ramoplanin, a new glycolipodepsipeptide antibiotic, and to four glycopeptides (vancomycin, teicoplanin, and two semisynthetic teicoplanin derivatives). Ramoplanin is recommended for further evaluation in the treatment of C. difficile-associated disease.

MeSH Terms
Anti-Bacterial Agents/pharmacology Clostridioides difficile/drug effects Depsipeptides Dose-Response Relationship, Drug Drug Resistance, Microbial Glycopeptides/pharmacology Humans Microbial Sensitivity Tests Peptides, Cyclic/pharmacology Ristocetin/analogs & derivatives Teicoplanin Vancomycin/pharmacology
Chemicals
Anti-Bacterial Agents Depsipeptides Glycopeptides Peptides, Cyclic ramoplanin MDL 62873 Ristocetin Teicoplanin Vancomycin teicoplanin aglycone
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Biavasco F
Institute of Microbiology, University of Ancona Medical School, Italy.
Manso E
Varaldo P E
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.35.1.195
Published
1991-01-00
Pages
195-7
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC244968
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.35.1.195 PMC Full Text View journal details
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