Transfer of allergic encephalomyelitis in rats by means of lymph node cells.

The Journal of experimental medicine ·Vol. 111 ·1960-01-01 ·Pages 119-36

PATERSON PY

Abstract

Transfer of allergic encephalomyelitis has been accomplished by injection of lymph node cells, obtained from donor rats sensitized to spinal cord, into recipient rats pretreated neonatally with normal rat spleen cells. Transfer of the disease may be achieved most frequently when the recipients are pretreated with spleen cells of the prospective lymph node cell donors. These transfers are attributed to the use of recipients which have acquired immunological tolerance to donor lymph node cells, as a result of the spleen cell pretreatment, and in which, therefore, the donor cells can survive and function longer after transfer.

Keywords

ENCEPHALOMYELITIS/experimental LYMPH NODES/physiology

MeSH Terms

Animals Encephalomyelitis Encephalomyelitis, Autoimmune, Experimental Immune Tolerance Lymph Nodes/physiology Lymphocytes Prospective Studies Rats Rats, Inbred Lew Spinal Cord Spleen

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

PATERSON P Y

References (28)

28 references, click to expand

Skin.
Transplant Bull. 1955;2:148-9 PMID: 12334405
Allergic encephalomyelitis in the rat induced by the intracutaneous injection of central nervous system tissue and adjuvants.
J Immunol. 1953 Aug;71(2):98-109 PMID: 13084920
A cytosieve permitting sterile preparation of suspensions of tumor cells for transplantation.
J Natl Cancer Inst. 1953 Jun;13(6):1511-5 PMID: 13097134
A method for the combined staining of cells and fibers in the nervous system.
J Neuropathol Exp Neurol. 1953 Oct;12(4):400-3 PMID: 13097193
The transfer of experimental allergic encephalomyelitis in the rat by means of parabiosis.
J Immunol. 1953 Nov;71(5):380-4 PMID: 13118176
Strain-specificity in tissue antigens of mice.
J Immunol. 1955 Jan;74(1):63-70 PMID: 13233521
The pathological effects produced by sera of animals immunized with foreign nervous or splenic tissue. I. Intracisternal injection of serum.
J Neurol Neurosurg Psychiatry. 1955 Aug;18(3):174-80 PMID: 13252425
Induction of tolerance to skin homografts in rats by injection of cells from the prospective donor soon after birth.
Br J Exp Pathol. 1955 Oct;36(5):494-9 PMID: 13269662
The influence of sex on isologous skin grafting in the mouse.
J Natl Cancer Inst. 1956 Jul;17(1):35-6 PMID: 13346339
A simple method for inducing tolerance of skin homografts in mice.
Transplant Bull. 1957 Apr;4(2):67-71 PMID: 13422625
Transfer of lymph node cells to recipient rabbits pre-injected with blood leucocytes of donors.
Proc Soc Exp Biol Med. 1957 May;95(1):26-30 PMID: 13431976
The effect of sex on skin grafts within inbred lines of mice.
Transplant Bull. 1957 Jul;4(3):110-2 PMID: 13455718
Further observation on the induction of tolerance of skin homografts in rats.
Transplant Bull. 1957 Oct;4(4):157-9 PMID: 13507162
Determination of cell viability.
Proc Soc Exp Biol Med. 1958 May;98(1):188-92 PMID: 13554587
The specificity of tolerance to homografts in the chicken.
J Immunol. 1958 Sep;81(3):246-52 PMID: 13575821
Studies on mammalian homotransplants of skin. I. Tolerance induced with a pooled antigen in rats.
Plast Reconstr Surg Transplant Bull. 1958 Nov;22(5):462-70 PMID: 13601153
Studies of immunological tolerance to nervous tissue in rats.
Ann N Y Acad Sci. 1958 Oct 7;73(3):811-8 PMID: 13617892
Acquired tolerance to homografts and heterografts in the rat.
Ann N Y Acad Sci. 1958 Oct 7;73(3):842-7 PMID: 13617896
Unexpected manifestations of induced tolerance to skin homografts in the chicken.
Ann N Y Acad Sci. 1958 Oct 7;73(3):862-8 PMID: 13617898
Long-term survival of intrastrain homografts in commercially bred rats.
Transplant Bull. 1959 Jan;6(1):97-100 PMID: 13635832
Quantitative studies of complement fixation. V. Estimation of complement-fixing potency of immune sera and its relation to antibody-nitrogen content.
J Immunol. 1950 Dec;65(6):661-73 PMID: 14803717
Diagnostic complement fixation. I. A method.
Am J Syph Gonorrhea Vener Dis. 1952 Mar;36(2):140-53 PMID: 14903424
Acute disseminated encephalomyelitis following immunization with homologous brain extracts; studies on the role of a circulating antibody in the production of the condition in dogs.
J Exp Med. 1950 Aug;92(2):133-52 PMID: 15428583
An investigation into the presence of antibodies and hypersensitivity in the encephalitis produced experimentally by the injection of homologous brain suspensions.
Bull Johns Hopkins Hosp. 1949 Apr;84(4):302-33 PMID: 18118603
Experimental disseminated encephalomyelitis in white mice.
J Exp Med. 1949 Sep;90(3):213-24 PMID: 18137295
Studies on acute disseminated encephalomyelitis produced experimentally in rhesus monkeys.
J Exp Med. 1948 Oct 1;88(4):417-26 PMID: 18884901
THE RAPID PRODUCTION OF ACUTE DISSEMINATED ENCEPHALOMYELITIS IN RHESUS MONKEYS BY INJECTION OF HETEROLOGOUS AND HOMOLOGOUS BRAIN TISSUE WITH ADJUVANTS.
J Exp Med. 1947 Jan 1;85(1):117-30 PMID: 19871595
ALLERGIC ENCEPHALOMYELITIS IN MONKEYS IN RESPONSE TO INJECTION OF NORMAL MONKEY NERVOUS TISSUE.
J Exp Med. 1947 Jan 1;85(1):131-40 PMID: 19871596

Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.111.1.119

Published

1960-01-01

Pages

119-36

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2137200

Subset

External Links

PubMed source DOI: 10.1084/jem.111.1.119 PMC Full Text View journal details

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Transfer of allergic encephalomyelitis in rats by means of lymph node cells.

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