Abstract
Mammalian macrophage scavenger receptors exhibit unusually broad binding specificity and are implicated in atherosclerosis and host defense. Scavenger receptor-like endocytosis was observed in Drosophila melanogaster embryos and in primary embryonic cell cultures. This receptor activity was expressed primarily by macrophages. The Drosophila Schneider L2, but not the Kc, cell line also exhibited a scavenger receptor-mediated endocytic pathway similar to its mammalian counterpart. L2 receptors mediated high-affinity internalization and subsequent temperature- and chloroquine-sensitive degradation of 125I-labeled acetylated low density lipoprotein and displayed characteristic ligand specificity. These findings suggest that scavenger receptors mediate important, well-conserved functions and raise the possibility that they may be pattern recognition receptors that arose early in the evolution of host defense mechanisms. They also establish additional systems for the investigation of endocytosis in Drosophila and scavenger receptor function in disease, host defense, and development.
MeSH Terms
Animals
Biological Transport/drug effects
Cell Line
Cells, Cultured
Chloroquine/pharmacology
Drosophila Proteins
Drosophila melanogaster/embryology,physiology
Embryo, Nonmammalian/physiology
Endocytosis
Kinetics
Lipoproteins, LDL/metabolism
Macrophages/drug effects,physiology
Membrane Proteins
Receptors, Immunologic/physiology
Receptors, Lipoprotein
Receptors, Scavenger
Scavenger Receptors, Class B
Scavenger Receptors, Class C
Chemicals
Drosophila Proteins
Lipoproteins, LDL
Membrane Proteins
Receptors, Immunologic
Receptors, Lipoprotein
Receptors, Scavenger
Scarb1 protein, mouse
Scavenger Receptors, Class B
Scavenger Receptors, Class C
Sr-CI protein, Drosophila
acetyl-LDL
Chloroquine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Abrams J M
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.
Lux A
Steller H
Krieger M
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