EFFECTS OF MINERALS ON NEOMYCIN PRODUCTION BY STREPTOMYCES FRADIAE.

Applied microbiology ·Vol. 13 ·1965-03-00 ·Pages 190-3

MAJUMDAR MK, MAJUMDAR SK

Abstract

A study was made on the mineral requirements of Streptomyces fradiae strain 3535 for neomycin production. It was observed that optimal levels of the elements Ca, Fe, and Zn per milliliter of a synthetic medium for neomycin production were 10.8, 1.0, and 0.115 mug, respectively. K(2)HPO(4) was required at a concentration of 0.1% for maximal yield of neomycin, whereas NaCl and the metals Mn and Cu were without any effect. High doses of Zn (0.23 mug/ml or above) caused destruction of neomycin after the fifth day of fermentation.

Keywords

CALCIUM CALCIUM CHLORIDE COPPER CULTURE MEDIA EXPERIMENTAL LAB STUDY FERMENTATION HYDROGEN-ION CONCENTRATION IRON MANGANESE METABOLISM NEOMYCIN PHARMACOLOGY PHOSPHATES POTASSIUM SODIUM CHLORIDE STREPTOMYCES ZINC

MeSH Terms

Calcium Calcium Chloride Calcium, Dietary Copper Culture Media Fermentation Hydrogen-Ion Concentration Iron Manganese Metabolism Minerals Neomycin Pharmacology Phosphates Potassium Research Sodium Chloride Streptomyces Zinc

Chemicals

Calcium, Dietary Culture Media Minerals Phosphates Manganese Sodium Chloride Copper Iron Neomycin Zinc Calcium Chloride Potassium Calcium

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

MAJUMDAR M K

MAJUMDAR S K

References (13)

13 references, click to expand

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Article Info

Journal

Applied microbiology

Abbr.

Appl Microbiol

ISSN

0003-6919

DOI

10.1128/am.13.2.190-193.1965

Published

1965-03-00

Pages

190-3

Language

English

Region

United States

NLM ID

7605802

PMCID

PMC1058219

Subset

External Links

PubMed source DOI: 10.1128/am.13.2.190-193.1965 PMC Full Text

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EFFECTS OF MINERALS ON NEOMYCIN PRODUCTION BY STREPTOMYCES FRADIAE.

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