Abstract
Rosenkranz, Herbert S. (Columbia University, New York, N.Y.), Howard S. Carr, and Harry M. Rose. Phenethyl alcohol. II. Effect on thymine-requiring Escherichia coli. J. Bacteriol. 89:1370-1373. 1965.-Phenethyl alcohol (PEA) at levels (0.05%) presumed to interfere with messenger ribonucleic acid synthesis also inhibits thymineless death, when the agent is added prior to the exponential killing phase. The addition of more concentrated solutions of PEA (0.5%) during this initial starvation leads to an immediate killing. Identical results were obtained when 0.5% PEA was added to cells growing in the presence of thymine. The addition of this high level (0.5%) of PEA to bacteria undergoing thymineless death results in the rescue of the survivors.
Keywords
ALCOHOLS
COLIPHAGES
ESCHERICHIA COLI
EXPERIMENTAL LAB STUDY
METABOLISM
PHARMACOLOGY
RNA
MESSENGER
THYMINE
MeSH Terms
Alcohols
Coliphages
Escherichia coli
Metabolism
Pharmacology
Phenylethyl Alcohol
RNA
RNA, Bacterial
RNA, Messenger
Research
Thymine
Chemicals
Alcohols
RNA, Bacterial
RNA, Messenger
RNA
Phenylethyl Alcohol
Thymine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
ROSENKRANZ H S
CARR H S
ROSE H M
References (20)
20 references, click to expand
-
THE MODE OF ACTION OF 5-FLUOROURACIL AND ITS DERIVATIVES.
Proc Natl Acad Sci U S A. 1958 Oct 15;44(10):1004-12
PMID: 16590300
-
Mutants of Escherichia coli requiring methionine or vitamin B12.
J Bacteriol. 1950 Jul;60(1):17-28
PMID: 15436457
-
Reversal of mutant phenotypes by 5-fluorouracil: an approach to nucleotide sequences in messenger-RNA.
Proc Natl Acad Sci U S A. 1962 Apr 15;48:532-46
PMID: 13877975
-
Thymine starvation and beta-galactosidase synthesis.
Biochim Biophys Acta. 1962 Apr 2;55:505-11
PMID: 14478073
-
THE ENZYMATIC METHYLATION OF RNA AND DNA, II. ON THE SPECIES SPECIFICITY OF THE METHYLATION ENZYMES.
Proc Natl Acad Sci U S A. 1963 Jul;50(1):164-9
PMID: 16578536
-
The induction of thymine synthesis by T2 infection of a thymine requiring mutant of Escherichia coli.
J Bacteriol. 1954 Jul;68(1):80-8
PMID: 13183905
-
Enzymatic adaptation in a thymine requiring strain of Escherichia coli.
J Bacteriol. 1955 Jan;69(1):59-66
PMID: 13233167
-
ENERGY REQUIREMENT FOR THYMINELESS DEATH IN CELLS OF ESCHERICHIA COLI.
J Bacteriol. 1964 Oct;88:987-90
PMID: 14219063
-
The origin of purine and pyrimidine deoxyribose in Escherichia coli systems.
J Biol Chem. 1959 Feb;234(2):360-3
PMID: 13630911
-
PHENETHYL ALCOHOL. I. EFFECT ON MACROMOLECULAR SYNTHESIS OF ESCHERICHIA COLI.
J Bacteriol. 1965 May;89:1354-69
PMID: 14293009
-
Protein synthesis and RNA turnover in a pyrimidine-deficient bacterium.
Biochim Biophys Acta. 1958 Oct;30(1):12-20
PMID: 13584390
-
Ribonucleic acid synthesis and thymineless death.
Biochim Biophys Acta. 1962 May 14;55:627-38
PMID: 13896401
-
STUDIES ON THE BACTERIOSTATIC ACTION OF HYDROXYLAMINE.
Biochim Biophys Acta. 1964 May 18;87:40-53
PMID: 14167432
-
Involvement of synthesis of RNA in thymineless death.
Nature. 1963 Apr 20;198:286
PMID: 13952474
-
THE ROLES OF INDUCER AND CATABOLITE REPRESSOR IN THE SYNTHESIS OF BETA-GALACTOSIDASE BY ESCHERICHIA COLI.
J Mol Biol. 1964 Jan;8:105-27
PMID: 14149954
-
The control of normal DNA replication in bacteria.
Cold Spring Harb Symp Quant Biol. 1961;26:45-52
PMID: 14467691
-
Thymine deficiency and the normal DNA replication cycle. I.
J Mol Biol. 1961 Apr;3:144-55
PMID: 13764647
-
Synchronization of division of a thymineless mutant of Escherichia coli.
J Bacteriol. 1956 Jul;72(1):115-23
PMID: 13345785
-
STUDIES ON UNBALANCED GROWTH IN ESCHERICHIA COLI.
Proc Natl Acad Sci U S A. 1954 Oct;40(10):885-93
PMID: 16589586
-
KINETICS OF INDUCED ENZYME SYNTHESIS. DETERMINATION OF THE MEAN LIFE OF GALACTOSIDASE-SPECIFIC MESSENGER RNA.
Biochim Biophys Acta. 1963 Oct 15;76:293-309
PMID: 14097386