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PMID: 14293009 Published · ppublish English Journal Article

PHENETHYL ALCOHOL. I. EFFECT ON MACROMOLECULAR SYNTHESIS OF ESCHERICHIA COLI.

Journal of bacteriology ·Vol. 89 ·1965-05-00 ·Pages 1354-69

ROSENKRANZ HS, CARR HS, ROSE HM

Abstract

Rosenkranz, Herbert S. (Columbia University, New York, N.Y.), Howard S. Carr, and Harry M. Rose. Phenethyl alcohol. I. Effect on macromolecular synthesis of Escherichia coli. J. Bacteriol. 89:1354-1369. 1965.-An investigation of the mode of action of phenethyl alcohol produced the following results. Phenethyl alcohol had no effect on the physicochemical properties of isolated deoxyribonucleic acid (DNA). The DNA isolated from phenethyl alcohol-treated bacteria had physicochemical properties identical with those of DNA isolated from normal cells. The metabolic functions most sensitive to the inhibitory action of phenethyl alcohol appeared to be the process of enzyme induction and, possibly, the synthesis of messenger ribonucleic acid. Phenethyl alcohol did not affect the polyuridylic acid-mediated synthesis of polyphenylalanine in a cell-free amino acid-incorporating system.

Keywords
ALCOHOLS ALKALINE PHOSPHATASE AMINO ACID METABOLISM ANTIMETABOLITES CARBON ISOTOPES CENTRIFUGATION DNA BACTERIAL ESCHERICHIA COLI EXPERIMENTAL LAB STUDY GLUCOSE METABOLISM HEAT MACROMOLECULAR SYSTEMS METABOLISM PHARMACOLOGY PHENYLALANINE RNA BACTERIAL RNA MESSENGER THYMIDINE
MeSH Terms
Alcohols Alkaline Phosphatase Amino Acids/metabolism Antimetabolites Carbon Isotopes Centrifugation DNA DNA, Bacterial Escherichia coli Glucose/metabolism Hot Temperature Macromolecular Substances Metabolism Peptides Pharmacology Phenylalanine Phenylethyl Alcohol Proteins RNA RNA, Bacterial RNA, Messenger Research Thymidine
Chemicals
Alcohols Amino Acids Antimetabolites Carbon Isotopes DNA, Bacterial Macromolecular Substances Peptides Proteins RNA, Bacterial RNA, Messenger Phenylalanine RNA DNA Alkaline Phosphatase Glucose Phenylethyl Alcohol Thymidine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
ROSENKRANZ H S
CARR H S
ROSE H M
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.89.5.1354-1369.1965
Published
1965-05-00
Pages
1354-69
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC277652
Subset
OM
External Links
PubMed source DOI: 10.1128/jb.89.5.1354-1369.1965 PMC Full Text View journal details
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