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PMID: 14247725 Published · ppublish English Journal Article

VIRUS PARTICLES IN THE THYMUS OF CONVENTIONAL AND GERM-FREE MICE.

The Journal of experimental medicine ·Vol. 120 ·1964-11-01 ·Pages 857-68

DEHARVEN E

Abstract

Electron microscope study of thymuses of both conventional and germ-free mice has revealed the presence of typical virus particles associated with the thymic lymphocytes or with the thymic epithelial cells. The particles resemble those associated with several murine leukemias and their viral nature seems convincingly substantiated by morphological observation. Germ-free mice are therefore not virus-free. The biological significance of these particles is still unknown and we can only speculate as to the possible relationship of these particles to the incidence of "spontaneous" leukemia, to the lymphocytosis stimulating factor of Metcalf, and to the numerous latent viral infections of laboratory mice.

Keywords
EXPERIMENTAL LAB STUDY GERM-FREE LIFE LEUKEMIA EXPERIMENTAL MAMMARY NEOPLASMS EXPERIMENTAL MICE MICROSCOPY ELECTRON MOUSE LEUKEMIA VIRUSES ONCOGENIC VIRUSES THYMUS GLAND
MeSH Terms
Animals Breast Neoplasms Electrons Germ-Free Life Humans Leukemia Virus, Murine Leukemia, Experimental Mammary Neoplasms, Animal Mammary Neoplasms, Experimental Mice Microscopy Microscopy, Electron Oncogenic Viruses Research Thymus Gland Virion
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
DEHARVEN E
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33 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.120.5.857
Published
1964-11-01
Pages
857-68
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2137866
Subset
OM
External Links
PubMed source DOI: 10.1084/jem.120.5.857 PMC Full Text View journal details
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