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PMID: 14025626 Published · ppublish English Journal Article

Evidence for a competitive antagonism of guanethidine by dexamphetamine.

British journal of pharmacology and chemotherapy ·Vol. 20 ·1963-02-00 ·Pages 17-28

DAY MD, RAND MJ

Abstract

After guanethidine had blocked the response of the cat nictitating membrane to sympathetic nerve stimulation, dexamphetamine restored the responses to all frequencies of stimulation. Dexamphetamine antagonized the sympathetic nerve block by guanethidine in the isolated sympathetically innervated rabbit ileum; the evidence suggests that the antagonism was competitive. Dexamphetamine antagonized the sympathetic nerve block by guanethidine in the isolated hypogastric nerve-vas deferens preparation of the guinea-pig. Doses of dexamphetamine, larger than those required to antagonize the blocking action of guanethidine, abolished the responses of the nictitating membrane, ileum and vas deferens to nerve stimulation. Dexamphetamine did not influence the depletion of noradrenaline by guanethidine in the heart and spleen of rabbits. The hypothesis is advanced that both dexamphetamine and guanethidine act on the store of noradrenaline at sympathetic nerve endings.

Keywords
DEXTRO AMPHETAMINE GUANETHIDINE NICTITATING MEMBRANE SYMPATHOLYTICS
MeSH Terms
Animals Cats Dextroamphetamine Guanethidine Guinea Pigs Humans Ileum Male Nictitating Membrane Norepinephrine Rabbits Sympathetic Nervous System Sympatholytics Vas Deferens
Chemicals
Sympatholytics Dextroamphetamine Norepinephrine Guanethidine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
DAY M D
RAND M J
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20 references, click to expand
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Article Info
Journal
British journal of pharmacology and chemotherapy
Abbr.
Br J Pharmacol Chemother
ISSN
0366-0826
DOI
10.1111/j.1476-5381.1963.tb01293.x
Published
1963-02-00
Pages
17-28
Language
English
Region
England
NLM ID
0154627
PMCID
PMC1703752
Subset
OM
External Links
PubMed source DOI: 10.1111/j.1476-5381.1963.tb01293.x PMC Full Text
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