Suppression of uric acid synthesis in the gouty human by the use of 6-diazo-5-oxo-L-norleucine.

The Journal of clinical investigation ·Vol. 39 ·1960-03-00 ·Pages 447-54

GRAYZEL AI, SEEGMILLER JE, LOVE E

Abstract

暂无摘要

Keywords

GOUT/therapy LEUCINE/related compounds URIC ACID/metabolism

MeSH Terms

Diazooxonorleucine Gout/therapy Humans Leucine/analogs & derivatives Uric Acid/metabolism

Chemicals

Diazooxonorleucine Uric Acid Leucine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

GRAYZEL A I

SEEGMILLER J E

LOVE E

References (18)

18 references, click to expand

The metabolism of choline and its conversion to glycine in the rat.
J Biol Chem. 1953 Sep;204(1):207-14 PMID: 13084592
Excessive uric acid production in the human induced by 2-ethylamino-1,3,4-thiadiazole.
Nature. 1959 May 23;183(4673):1463-4 PMID: 13657171
Clinical trials of O-diazoacetyl-L-serine (azaserine) in neoplastic disease.
Cancer. 1954 Jul;7(4):801-14 PMID: 13172694
Inhibition of uric acid biosynthesis in birds by o-diazoacetyl-L-serine (azaserine) and 6-diazo-5-oxo-L-norleucine (DON).
Am J Physiol. 1958 Oct;195(1):244-50 PMID: 13583156
Failure to detect consistent overincorporation of glycine-1-C14 into uric acid in primary gout.
Metabolism. 1958 Jul;7(4 Pt 1):376-7 PMID: 13565392
The enzymatic spectrophotometric method for determination of uric acid.
J Lab Clin Med. 1959 Dec;54:903-13 PMID: 14416793
Incorporation of glycine nitrogen into uric acid in normal and gouty man.
Metabolism. 1952 Jan;1(1):3-12 PMID: 14890550
Control of pyrimidine biosynthesis in Escherichia coli by a feed-back mechanism.
J Biol Chem. 1956 Aug;221(2):757-70 PMID: 13357469
Pharmacological and initial therapeutic observations on 6-diazo-5-oxo-1-norleucine (DON) in human neoplastic disease.
Cancer. 1957 Nov-Dec;10(6):1138-50 PMID: 13489662
Overproduction of uric acid as the cause of hyperuricemia in primary gout.
J Clin Invest. 1957 Oct;36(10):1508-15 PMID: 13475488
The regulation of activity of phosphoribosyl-pyrophosphate amidotransferase by purine ribonacleotides: a potential feedback control of purine biosyntoesis.
J Biol Chem. 1959 Jun;234(6):1492-6 PMID: 13654403
The relation of dietary nitrogen consumption to the rate of uric acid synthesis in normal and gouty man.
J Clin Invest. 1953 Aug;32(8):778-80 PMID: 13069626
Incorporation of 4-amino-5-imidazolecarboxamide-4-C13 into uric acid in the normal human.
J Biol Chem. 1955 Oct;216(2):653-62 PMID: 13271342
The metabolism of uric acid in the normal and gouty human studied with the aid of isotopic uric acid.
J Biol Chem. 1949 Nov;181(1):183-93 PMID: 15390405
Incorporation of glycine-1-C14, glycine-2-C14 and glycine-N15 into uric acid in normal and gouty subjects.
Am J Med. 1958 Dec;25(6):917-32 PMID: 13606143
Biosynthesis of the purines. XV. The effect of aza-L-serine and 6-diazo-5-oxo-L-norleucine on inosinic acid biosynthesis de novo.
J Biol Chem. 1957 Mar;225(1):163-76 PMID: 13416227
Studies of the uricogenic effect of 2-substituted thiadiazoles in man.
J Clin Invest. 1959 Jun;38(6):907-15 PMID: 13654527
A microcolorimetric determination of creatine in urine by the Jaffe reaction.
J Biol Chem. 1954 Jun;208(2):853-61 PMID: 13174594

Article Info

Journal

The Journal of clinical investigation

Abbr.

J Clin Invest

ISSN

0021-9738

DOI

10.1172/JCI104057

Published

1960-03-00

Pages

447-54

Language

English

Region

United States

NLM ID

7802877

PMCID

PMC293323

Subset

External Links

PubMed source DOI: 10.1172/JCI104057 PMC Full Text View journal details

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Suppression of uric acid synthesis in the gouty human by the use of 6-diazo-5-oxo-L-norleucine.

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