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PMID: 1355604 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Expression pattern of a murine homeobox gene, Dbx, displays extreme spatial restriction in embryonic forebrain and spinal cord.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 89 ·No. 17 ·1992-09-01 ·Pages 8053-7

Lu S, Bogarad LD, Murtha MT, Ruddle FH

Abstract

Homeobox genes specify regional identity during development. A homeobox sequence that we have named Dbx was isolated from 13.5-day embryonic mouse telencephalon cDNA. The Dbx homeodomain shows highest sequence homology to Drosophila H2.0 and chicken CHox E. We report here the expression pattern of Dbx during mouse embryogenesis. In situ hybridization analyses indicate that Dbx is expressed exclusively within the embryonic central nervous system in a highly restricted manner. Dbx transcripts are detected within a region of the prospective cerebral cortex of the midgestation telencephalon. Dbx is also expressed in the diencephalon as well as in two thin continuous columns of neuroblasts within the hindbrain and spinal cord. This expression is limited to regions of active mitosis. Dbx may act to specify subsets of neuroblasts during the development of the central nervous system.

Related Genes
Antp CHox E Dbx Hlx dH2.0
MeSH Terms
Amino Acid Sequence Animals Brain/embryology Cloning, Molecular DNA/genetics Gene Expression Genes, Homeobox Gestational Age Mice/embryology Molecular Sequence Data Nucleic Acid Hybridization RNA, Messenger/genetics
Chemicals
RNA, Messenger DNA
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Lu S
Department of Biology, Yale University, New Haven, CT 06511.
Bogarad L D
Murtha M T
Ruddle F H
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.89.17.8053
Published
1992-09-01
Pages
8053-7
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC49854
Subset
IM
Grants
NIGMS NIH HHS · GM09966 · United States
NICHD NIH HHS · HD07412 · United States
External Links
PubMed source DOI: 10.1073/pnas.89.17.8053 PMC Full Text View journal details
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