Home LiteratureArticle Details
PMID: 13539198 Published · ppublish English Journal Article

On the mechanism of overproduction of uric acid in patients with primary gout.

The Journal of clinical investigation ·Vol. 37 ·No. 4 ·1958-04-00 ·Pages 579-90

WYNGAARDEN JB, BLAIR AE, HILLEY L

Abstract

暂无摘要

Keywords
GOUT/urine in URIC ACID/metabolism
MeSH Terms
Gout/urine Humans Hyperuricemia Uric Acid/metabolism
Chemicals
Uric Acid
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
WYNGAARDEN J B
BLAIR A E
HILLEY L
References (28)
28 references, click to expand
  1. Nucleotide metabolism. II. Chromatographic separation of acid-soluble nucleotides.
    J Biol Chem. 1954 Jul;209(1):23-39 PMID: 13192056
  2. Intermediary purine metabolism and the metabolic defects of gout.
    Metabolism. 1957 May;6(3):244-68 PMID: 13430358
  3. Biosynthesis of nucleic acid purines. I. Formation of guanine from adenine compounds in bone marrow extracts.
    Arch Biochem Biophys. 1955 May;56(1):184-95 PMID: 14377564
  4. The enzymic oxidation and assay of adenine.
    Biochem J. 1952 Jan;50(3):404-7 PMID: 14915965
  5. The purine bases of human urine. II. Semiquantitative estimation and isotope incorporation.
    J Biol Chem. 1957 Jan;224(1):423-34 PMID: 13398418
  6. A simultaneous study of glycine-N15 incorporation into uric acid and heme, and of Fe59 utilization, in a case of gout associated with polycythemia secondary to congenital heart disease.
    Am J Med. 1953 Dec;15(6):845-6 PMID: 13104455
  7. Biosynthesis of the purines. III. Reactions of formate and inosinic acid and an effect of the citrovorum factor.
    J Biol Chem. 1953 May;202(1):241-52 PMID: 13061451
  8. Incorporation of glycine nitrogen into uric acid in normal and gouty man.
    Metabolism. 1952 Jan;1(1):3-12 PMID: 14890550
  9. Renal function in gout; with a commentary on the renal regulation of urate excretion, and the role of the kidney in the pathogenesis of gout.
    Am J Med. 1957 Oct;23(4):600-22 PMID: 13469831
  10. Biosynthesis of the purines. VI. Purification of liver nucleoside phosphorylase and demonstration of nucleoside synthesis from 4-amino-5-imidazolecarboxamide, adenine, and 2, 6-diaminopurine.
    J Biol Chem. 1955 Nov;217(1):183-91 PMID: 13271381
  11. On the occurrence of glycinamide ribotide and its formyl derivative.
    J Biol Chem. 1956 Aug;221(2):555-67 PMID: 13357450
  12. Chromatographic investigation of purines in normal human urine.
    Proc Soc Exp Biol Med. 1954 Oct;87(1):257-60 PMID: 13224743
  13. On the biosynthesis of uric acid from glycine-N15 in primary and secondary polycythemia.
    Am J Med. 1956 Dec;21(6):901-17 PMID: 13372568
  14. The purine bases of human urine. I. Separation and identification.
    J Biol Chem. 1957 Jan;224(1):407-22 PMID: 13398417
  15. De novo synthesis of hypoxanthine via inosine-5-phosphate and inosine.
    J Biol Chem. 1951 Jun;190(2):611-31 PMID: 14841212
  16. Biosynthesis of the purines. VII. Synthesis of nucleotides from bases by partially purified enzymes.
    J Biol Chem. 1955 Dec;217(2):875-83 PMID: 13271448
  17. Overproduction of uric acid as the cause of hyperuricemia in primary gout.
    J Clin Invest. 1957 Oct;36(10):1508-15 PMID: 13475488
  18. Studies on uric acid and related compounds. III. Observations on the specificity of mammalian xanthine oxidases.
    J Biol Chem. 1956 Dec;223(2):765-80 PMID: 13385225
  19. Recent contributions to the understanding of the metabolic defect in gout.
    Geriatrics. 1954 Apr;9(4):163-71 PMID: 13151400
  20. Windowless, Flow Type, Proportional Counter for Counting C14.
    Science. 1950 Aug 18;112(2903):198-9 PMID: 17759216
  21. 2, 6-Diaminopurine as substrate and inhibitor of xanthine oxidase.
    J Biol Chem. 1957 Jan;224(1):453-62 PMID: 13398421
  22. The concept of secondary gout; relation to purine metabolism in polycythemia and myeloid metaplasia.
    Trans Assoc Am Physicians. 1956;69:229-38 PMID: 13380967
  23. Erythrocyte metabolism. I. Purine nucleoside phosphorylase.
    J Biol Chem. 1956 Aug;221(2):971-81 PMID: 13357491
  24. Biosynthesis of the purines. I. Hypoxanthine formation in pigeon liver homogenates and extracts.
    J Biol Chem. 1952 May;196(2):499-512 PMID: 12980993
  25. The Identification of Guanine in Extracts of Girella Nigricans: The Specificity of Guanase.
    Proc Natl Acad Sci U S A. 1944 Oct 15;30(10):294-7 PMID: 16578130
  26. Uric acid production in a case of myeloid metaplasia associated with gouty arthritis, studied with N15 labeled glycine.
    Am J Med. 1953 Dec;15(6):857-61 PMID: 13104456
  27. Enzymatic synthesis of adenosine-5'-phosphate from inosine-5'-phosphate.
    J Biol Chem. 1956 Nov;223(1):327-39 PMID: 13376602
  28. A further study of the utilization of dietary glycine nitrogen for uric acid synthesis in gout.
    J Clin Invest. 1953 Aug;32(8):775-7 PMID: 13069625
Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
Published
1958-04-00
Pages
579-90
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC293124
Subset
OM
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com