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PMID: 1352754 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex.

The EMBO journal ·Vol. 11 ·No. 7 ·1992-07-00 ·Pages 2541-50

Simeone A, Gulisano M, Acampora D, Stornaiuolo A, Rambaldi M, Boncinelli E

Abstract

We cloned two homeobox genes, Emx1 and Emx2, related to empty spiracles, a gene expressed in very anterior body regions during early Drosophila embryogenesis, and studied their expression in mouse embryos. Emx1 expression is detectable from day 9.5 of gestation whereas Emx2 appears to be already expressed in 8.5 day embryos. Both genes are expressed in the presumptive cerebral cortex and olfactory bulbs. Emx1 is expressed exclusively there, whereas Emx2 is also expressed in some neuroectodermal areas in embryonic head including olfactory placodes in earlier stages and olfactory epithelia later in development.

Related Genes
Emx1 Emx2
MeSH Terms
Amino Acid Sequence Animals Blotting, Northern Cerebral Cortex/embryology,metabolism Cloning, Molecular DNA Drosophila/genetics Female Gene Expression Genes, Homeobox Mice Mice, Inbred C57BL Molecular Sequence Data Nucleic Acid Hybridization Pregnancy RNA Probes Sequence Homology, Nucleic Acid
Chemicals
RNA Probes DNA
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Simeone A
International Institute of Genetics and Biophysics, CNR, Naples, Italy.
Gulisano M
Acampora D
Stornaiuolo A
Rambaldi M
Boncinelli E
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1992-07-00
Pages
2541-50
Language
English
Region
England
NLM ID
8208664
PMCID
PMC556729
Subset
IM
Databases
GENBANK
X66291, X66292, X66293, X66294, X67725, X67726, X68879, X68880, X68881, X68882
External Links
PubMed source PMC Full Text View journal details
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