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PMID: 2574852 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The human HOX gene family.

Nucleic acids research ·Vol. 17 ·No. 24 ·1989-12-25 ·Pages 10385-402

Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E

Abstract

We report the identification of 10 new human homeobox sequences. Altogether, we have isolated and sequenced 30 human homeoboxes clustered in 4 chromosomal regions called HOX loci. HOX1 includes 8 homeoboxes in 90 kb of DNA on chromosome 7. HOX2 includes 9 homeoboxes in 180 kb on chromosome 17. HOX3 contains at least 7 homeoboxes in 160 kb on chromosome 12. Finally, HOX4 includes 6 homeoboxes in 70 kb on chromosome 2. Homeodomains obtained from the conceptual translation of the isolated homeoboxes can be attributed to 13 homology groups on the basis of their primary peptide sequence. Moreover, it is possible to align the 4 HOX loci so that corresponding homeodomains in all loci share the maximal sequence identity. The complex of these observations supports and extends an evolutionary hypothesis concerning the origin of mammalian and fly homeobox gene complexes. We also determined the coding region present in 3 HOX2 cDNA clones corresponding to HOX2G, HOX2H and HOX2I.

MeSH Terms
Amino Acid Sequence Base Sequence Cloning, Molecular DNA/genetics DNA Probes Exons Genes, Homeobox Humans Introns Molecular Sequence Data Restriction Mapping Sequence Homology, Nucleic Acid
Chemicals
DNA Probes DNA
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Acampora D
International Institute of Genetics and Biophysics, CNR, Naples, Italy.
D'Esposito M
Faiella A
Pannese M
Migliaccio E
Morelli F
Stornaiuolo A
Nigro V
Simeone A
Boncinelli E
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30 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/17.24.10385
Published
1989-12-25
Pages
10385-402
Language
English
Region
England
NLM ID
0411011
PMCID
PMC335308
Subset
IM
Databases
GENBANK
X16665, X16666, X16667
External Links
PubMed source DOI: 10.1093/nar/17.24.10385 PMC Full Text View journal details
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