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PMID: 1348081 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Identification of a novel surface protein on activated CD4+ T cells that induces contact-dependent B cell differentiation (help).

The Journal of experimental medicine ·Vol. 175 ·No. 4 ·1992-04-01 ·Pages 1091-101

Lederman S, Yellin MJ, Krichevsky A, Belko J, Lee JJ, Chess L

Abstract

CD4+ T lymphocytes provide contact-dependent stimuli to B cells that are critical for the generation of specific antibody responses in a process termed T helper function. The surface structures on activated CD4+ T cells that mediate this function are not fully known. We previously reported the isolation of a functionally unique subclone of the Jurkat leukemic T cell line (D1.1) that constitutively expressed contact-dependent helper effector function. To identify T cell surface molecules that mediate contact-dependent T helper function, a monoclonal antibody (mAb), designated 5c8, was generated that inhibits D1.1-mediated B cell activation and immunoprecipitates a novel 30-kD protein structure from surface-iodinated D1.1 cells. Normal CD4+ T cells express 5c8 antigen (Ag) transiently 5-6 h after activation by phorbol myristate acetate and phytohemagglutinin with maximal expression 5-6 h after activation and absence of expression by 24 h. In contrast, neither resting nor activated CD8+ T cells express 5c8 Ag. In functional studies, mAb 5c8 inhibits the ability of fixed, activated CD4+ T cells to induce B cell surface CD23 expression. In addition, mAb 5c8 inhibits the ability of CD4+ T cells to direct terminal B cell differentiation driven by pokeweed mitogen. Taken together, these data suggest that 5c8 Ag is a novel, activation-induced surface T cell protein that is involved in mediating a contact-dependent element of the helper effector function of CD4+ T lymphocytes.

MeSH Terms
Antibodies, Monoclonal/immunology Antigens, Differentiation, B-Lymphocyte/analysis Antigens, Surface/physiology B-Lymphocytes/immunology CD4-Positive T-Lymphocytes/immunology CD8 Antigens/analysis Cell Adhesion Cell Communication Cell Differentiation Flow Cytometry Gene Expression Humans In Vitro Techniques Lymphocyte Activation Lymphocyte Cooperation Precipitin Tests Receptors, Fc/analysis Receptors, IgE T-Lymphocyte Subsets/immunology T-Lymphocytes, Helper-Inducer/immunology
Chemicals
Antibodies, Monoclonal Antigens, Differentiation, B-Lymphocyte Antigens, Surface CD8 Antigens Receptors, Fc Receptors, IgE
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Lederman S
Department of Medicine, Columbia University, New York, New York 10032.
Yellin M J
Krichevsky A
Belko J
Lee J J
Chess L
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
Published
1992-04-01
Pages
1091-101
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2119166
Subset
IM
Grants
NIAID NIH HHS · AI-07132 · United States
NIAID NIH HHS · P01-AI-26886 · United States
NIAID NIH HHS · R0-1-AI-14969 · United States
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