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PMID: 1320373 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The herpes simplex virus immediate-early protein ICP27 stimulates the transcription of cellular Alu repeated sequences by increasing the activity of transcription factor TFIIIC.

The Biochemical journal ·Vol. 284 ( Pt 3) ·1992-06-15 ·Pages 667-73

Jang KL, Latchman DS

Abstract

Infection with herpes simplex virus (HSV) results in an increase in the transcription of the endogenous Alu repeated sequence by RNA polymerase III. This effect is also observed in uninfected cells stably transformed with a plasmid expressing the HSV immediate-early protein ICP27 or in cells transfected with the gene encoding this protein. Both uninfected cells expressing ICP27 and cells infected with virus producing functional ICP27 display increased activity of the cellular transcription factor TFIIIC when compared with untreated cells. This increase is not observed, however, in cells infected with a mutant strain of virus which does not produce ICP27. Hence ICP27 induces elevated Alu transcription by activating transcription factor TFIIIC, which is the limiting factor for such transcription. This is the first report of increased activity of a cellular transcription factor during HSV infection, when most cellular gene activity is inhibited.

MeSH Terms
Animals Base Sequence Cell Line, Transformed Cell Nucleus/physiology Cycloheximide/pharmacology DNA/genetics,metabolism Dactinomycin/pharmacology HeLa Cells Humans Immediate-Early Proteins Molecular Sequence Data Oligodeoxyribonucleotides Polymerase Chain Reaction/methods Repetitive Sequences, Nucleic Acid Simplexvirus/genetics Trans-Activators/metabolism Transcription Factors/metabolism Transcription Factors, TFIII Transcription, Genetic/drug effects Transfection Vero Cells Viral Proteins/genetics,metabolism
Chemicals
ICP27 protein, human herpesvirus 1 Immediate-Early Proteins Oligodeoxyribonucleotides Trans-Activators Transcription Factors Transcription Factors, TFIII Viral Proteins transcription factor TFIIIC Dactinomycin DNA Cycloheximide
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Jang K L
Department of Biochemistry, University College and Middlesex School of Medicine, London, U.K.
Latchman D S
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj2840667
Published
1992-06-15
Pages
667-73
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1132590
Subset
IM
External Links
PubMed source DOI: 10.1042/bj2840667 PMC Full Text View journal details
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