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PMID: 2821506 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Transcriptional induction of the ubiquitin gene during herpes simplex virus infection is dependent upon the viral immediate-early protein ICP4.

Nucleic acids research ·Vol. 15 ·No. 18 ·1987-09-25 ·Pages 7283-93

Latchman DS, Estridge JK, Kemp LM

Abstract

Lytic infection with herpes simplex virus results in transcriptional induction of a cellular gene encoding ubiquitin, causing increased accumulation of ubiquitin RNA and protein in the infected cell. This induction, which is dependent upon viral protein synthesis, does not occur in the HSV-1 mutant tsK which is defective in the gene encoding the viral protein ICP4. Transfected cells expressing the viral ICP4 protein exhibit higher levels of ubiquitin gene transcription than untransfected controls indicating that transcriptional induction can be mediated by the ICP4 protein alone.

MeSH Terms
Animals Cell Line Cricetinae Fibroblasts/metabolism Gene Expression Regulation Immediate-Early Proteins Simplexvirus/genetics,physiology Transcription, Genetic Ubiquitins/biosynthesis,genetics Viral Proteins/genetics,physiology Virus Replication
Chemicals
Immediate-Early Proteins Ubiquitins Viral Proteins herpes simplex virus, type 1 protein ICP4
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Latchman D S
Department of Zoology and Cell Biology, University College, London, UK.
Estridge J K
Kemp L M
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/15.18.7283
Published
1987-09-25
Pages
7283-93
Language
English
Region
England
NLM ID
0411011
PMCID
PMC306248
Subset
IM
External Links
PubMed source DOI: 10.1093/nar/15.18.7283 PMC Full Text View journal details
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