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PMID: 1315048 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Marek disease virus encodes a basic-leucine zipper gene resembling the fos/jun oncogenes that is highly expressed in lymphoblastoid tumors.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 89 ·No. 9 ·1992-05-01 ·Pages 4042-6

Jones D, Lee L, Liu JL, Kung HJ, Tillotson JK

Abstract

Marek disease virus (MDV) is a herpesvirus of chickens that induces T lymphomas within 3 weeks of infection. The short latency and polyclonal nature of MDV-induced tumors have suggested that the virus may encode one or more direct-acting oncogenes. To date, however, no MDV-specific tumor antigens or candidate transforming genes have been demonstrated. In this paper, we report the identification of a MDV gene encoding a protein with homology to the leucine-zipper class of nuclear oncogenes. It also contains a proline-rich domain characteristic of another class of transcription factors. This gene, designated meq, maps to the long repeat of MDV and is one of the few genes that are highly expressed in MDV-induced T-cell tumors. To our knowledge, a herpesvirus gene closely related to the fos/jun family of oncogenes has not been reported previously.

Related Genes
fos jun meq
MeSH Terms
Amino Acid Sequence Base Sequence Blotting, Western DNA-Binding Proteins/genetics Gene Expression Genes, Viral Herpesvirus 2, Gallid/genetics Leucine Zippers Lymphoma, T-Cell/genetics Molecular Sequence Data Molecular Weight Multigene Family Oligodeoxyribonucleotides/chemistry Promoter Regions, Genetic RNA, Messenger/genetics Sequence Alignment Transcription, Genetic Viral Structural Proteins/genetics
Chemicals
DNA-Binding Proteins Oligodeoxyribonucleotides RNA, Messenger Viral Structural Proteins
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Jones D
Department of Molecular Biology and Microbiology, Case Western Reserve University, School of Medicine, Cleveland, OH 44106.
Lee L
Liu J L
Kung H J
Tillotson J K
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.89.9.4042
Published
1992-05-01
Pages
4042-6
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC525628
Subset
IM
Grants
NCI NIH HHS · CA46613 · United States
NCI NIH HHS · P-30 CA43703 · United States
Databases
GENBANK
M89471
Corrections
ErratumIn
-
External Links
PubMed source DOI: 10.1073/pnas.89.9.4042 PMC Full Text View journal details
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