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PMID: 1313578 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 89 ·No. 7 ·1992-04-01 ·Pages 3060-4

Ip NY, Ibáñez CF, Nye SH, McClain J, Jones PF, Gies DR, Belluscio L, Le Beau MM, Espinosa R, Squinto SP

Abstract

Nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 (NT-3) are the three members of the neurotrophin family known to exist in mammals. Recently, a fourth neurotrophin (designated neurotrophin-4 or NT-4), which shares all of the features found in the mammalian neurotrophins, has been identified in Xenopus and viper. We used sequences specific to the Xenopus/viper NT-4 to isolate a neurotrophin from both human and rat genomic DNA that appears to represent the mammalian counterpart of Xenopus/viper NT-4. Human NT-4 as well as a human NT-4 pseudogene colocalize to chromosome 19 band q13.3. Mammalian NT-4 has many unusual features compared to the previously identified neurotrophins and is less conserved evolutionarily than the other neurotrophins. However, mammalian NT-4 displays bioactivity and trk receptor specificity similar to that of Xenopus NT-4.

MeSH Terms
3T3 Cells Amino Acid Sequence Animals Chromosome Mapping Chromosomes, Human, Pair 19 Cloning, Molecular Gene Expression Genes Humans Mice Molecular Sequence Data Nerve Growth Factors/genetics,metabolism Polymerase Chain Reaction Proto-Oncogene Proteins/physiology Pseudogenes RNA, Messenger/genetics Rats Receptor, trkA Receptors, Cell Surface Sequence Alignment Tissue Distribution
Chemicals
Nerve Growth Factors Proto-Oncogene Proteins RNA, Messenger Receptors, Cell Surface Receptor, trkA neurotrophin 4
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Ip N Y
Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591.
Ibáñez C F
Nye S H
McClain J
Jones P F
Gies D R
Belluscio L
Le Beau M M
Espinosa R
Squinto S P
References (32)
32 references, click to expand
  1. New protein fold revealed by a 2.3-A resolution crystal structure of nerve growth factor.
    Nature. 1991 Dec 5;354(6352):411-4 PMID: 1956407
  2. Molecular cloning and expression of brain-derived neurotrophic factor.
    Nature. 1989 Sep 14;341(6238):149-52 PMID: 2779653
  3. Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family.
    Nature. 1990 Mar 22;344(6264):339-41 PMID: 2314473
  4. NT-3, BDNF, and NGF in the developing rat nervous system: parallel as well as reciprocal patterns of expression.
    Neuron. 1990 Oct;5(4):501-9 PMID: 1688327
  5. Primary structure and biological activity of a novel human neurotrophic factor.
    Neuron. 1990 May;4(5):767-73 PMID: 2344409
  6. The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3.
    Cell. 1991 Jul 12;66(1):173-83 PMID: 1649007
  7. Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain.
    Proc Natl Acad Sci U S A. 1990 Jul;87(14):5454-8 PMID: 2164684
  8. The receptor for ciliary neurotrophic factor.
    Science. 1991 Jul 5;253(5015):59-63 PMID: 1648265
  9. Brain-derived neurotrophic factor prevents neuronal death in vivo.
    Nature. 1988 Jan 21;331(6153):261-2 PMID: 3336438
  10. Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations.
    Genomics. 1991 Jul;10(3):558-68 PMID: 1889806
  11. Neurotrophin-3: a neurotrophic factor related to NGF and BDNF.
    Science. 1990 Mar 23;247(4949 Pt 1):1446-51 PMID: 2321006
  12. Cloning and expression of a cDNA encoding a novel human neurotrophic factor.
    FEBS Lett. 1990 Jun 18;266(1-2):187-91 PMID: 2365067
  13. The trk proto-oncogene product: a signal transducing receptor for nerve growth factor.
    Science. 1991 Apr 26;252(5005):554-8 PMID: 1850549
  14. Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB.
    Neuron. 1991 Nov;7(5):857-66 PMID: 1742028
  15. Mapping chromosome band 11q23 in human acute leukemia with biotinylated probes: identification of 11q23 translocation breakpoints with a yeast artificial chromosome.
    Proc Natl Acad Sci U S A. 1990 Dec;87(23):9358-62 PMID: 2251277
  16. Transient and persistent expression of NT-3/HDNF mRNA in the rat brain during postnatal development.
    J Neurosci. 1991 Jun;11(6):1577-84 PMID: 2045877
  17. Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family.
    Neuron. 1990 Oct;5(4):511-26 PMID: 2206535
  18. trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3.
    Cell. 1991 Sep 6;66(5):967-79 PMID: 1653651
  19. Widespread expression of BDNF but not NT3 by target areas of basal forebrain cholinergic neurons.
    Science. 1990 Oct 12;250(4978):290-4 PMID: 1688328
  20. Two conserved domains in the NGF propeptide are necessary and sufficient for the biosynthesis of correctly processed and biologically active NGF.
    EMBO J. 1991 Sep;10(9):2395-400 PMID: 1868828
  21. trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor.
    Cell. 1991 May 31;65(5):885-93 PMID: 1710174
  22. Molecular cloning of a human gene that is a member of the nerve growth factor family.
    Proc Natl Acad Sci U S A. 1990 Oct;87(20):8060-4 PMID: 2236018
  23. Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary.
    Neuron. 1991 May;6(5):845-58 PMID: 2025430
  24. The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor.
    Cell. 1991 May 31;65(5):895-903 PMID: 1645620
  25. Placodal sensory neurons in culture: nodose ganglion neurons are unresponsive to NGF, lack NGF receptors but are supported by a liver-derived neurotrophic factor.
    Dev Biol. 1985 Nov;112(1):30-48 PMID: 2996959
  26. TrkB mediates BDNF/NT-3-dependent survival and proliferation in fibroblasts lacking the low affinity NGF receptor.
    Cell. 1991 Jul 26;66(2):405-13 PMID: 1649703
  27. The trk proto-oncogene rescues NGF responsiveness in mutant NGF-nonresponsive PC12 cell lines.
    Cell. 1991 Sep 6;66(5):961-6 PMID: 1653650
  28. The trk proto-oncogene encodes a receptor for nerve growth factor.
    Cell. 1991 Apr 5;65(1):189-97 PMID: 1849459
  29. The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3.
    Cell. 1991 Jul 26;66(2):395-403 PMID: 1649702
  30. Cells that Express Brain-Derived Neurotrophic Factor mRNA in the Developing Postnatal Rat Brain.
    Eur J Neurosci. 1991 Jul;3(7):688-697 PMID: 12106476
  31. Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF.
    Nature. 1991 Mar 14;350(6314):158-60 PMID: 1706478
  32. Neurotrophic molecules.
    Ann Neurol. 1989 Oct;26(4):489-506 PMID: 2684002
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.89.7.3060
Published
1992-04-01
Pages
3060-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC48803
Subset
IM
Grants
NCI NIH HHS · CA40046 · United States
Databases
GENBANK
M86528, M86529, M86742
External Links
PubMed source DOI: 10.1073/pnas.89.7.3060 PMC Full Text View journal details
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