Origin of the extra chromosome no. 21 in Down's syndrome.

Human genetics ·Vol. 32 ·No. 1 ·1976-04-15 ·Pages 13-6

Wagenbichler P, Killian W, Rett A, Schnedl W

Abstract

Eighteen of 38 examined families with children with Down's syndrome showed polymorphisms of chromosome 21 elucidating the origin of the extra chromosome 21. Maternal origin was found in 10 cases and paternal origin in 8 cases. In both sexes errors occurred both in the first and in the second meiotic division.

MeSH Terms

Adult Age Factors Chromosomes, Human, 21-22 and Y Down Syndrome/genetics Female Humans Male Meiosis Middle Aged Parents Pedigree Polymorphism, Genetic Sex Factors

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Wagenbichler P

Killian W

Rett A

Schnedl W

References (6)

6 references, click to expand

Analysis of the human karyotype by the recent banding techniques.
Arch Genet (Zur). 1973;46(2):65-98 PMID: 4131243
Difference in fluorescence of the homologe chromosomes No. 3 in man.
Humangenetik. 1971;12(1):59-63 PMID: 4104179
Trisomy 21 in man due to maternal non-disjunction during the first meiotic division.
Hereditas. 1972;70(1):153-4 PMID: 4281765
Polymporphism of human C-band heterochromatin. II. Family studies with suggestive evidence for somatic crossing over.
Am J Hum Genet. 1975 Mar;27(2):178-89 PMID: 47710
Origin of the trisomic 21 chromosome.
Lancet. 1973 Feb 17;1(7799):375 PMID: 4121971
Origin of extra chromosome in trisomy 21.
Lancet. 1973 Jan 20;1(7795):131-3 PMID: 4118469

Article Info

Journal

Human genetics

Abbr.

Hum Genet

ISSN

0340-6717

DOI

10.1007/BF00569971

Published

1976-04-15

Pages

13-6

Language

English

Region

Germany

NLM ID

7613873

Subset

External Links

PubMed source DOI: 10.1007/BF00569971 View journal details

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Origin of the extra chromosome no. 21 in Down's syndrome.

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