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PMID: 47710 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Polymporphism of human C-band heterochromatin. II. Family studies with suggestive evidence for somatic crossing over.

American journal of human genetics ·Vol. 27 ·No. 2 ·1975-03-00 ·Pages 178-89

Craig-Holmes AP, Moore FB, Shaw MW

Abstract

An analysis of the inherited pattern of C-band heterochromatin has been made in five pedigrees containing a total of 33 offspring that were available for analysis. The majority of variants were found to be inherited; however, at least seven of the 99 variants were not present in either parent, and an additional seven differed from the parental variant by either a morphological change or the appearance of mosaicism. It is believed that the polymorphism of human constitutive heterochromatin arises from a mismatching of the repetitive DNA sequences contained in these regions with subsequent unequal crossing over. Further, the observed mosaic patterns provide suggestive evidence that such an event occurs in somatic cells as well as during meiosis.

MeSH Terms
Blood Group Antigens Chromosomes/ultrastructure Crossing Over, Genetic Female Genetic Linkage Genetic Variation Heterochromatin Humans Karyotyping Leukocytes/ultrastructure Male Meiosis Mosaicism Pedigree Phenotype Polymorphism, Genetic Staining and Labeling
Chemicals
Blood Group Antigens Heterochromatin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Craig-Holmes A P
Moore F B
Shaw M W
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30 references, click to expand
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Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Published
1975-03-00
Pages
178-89
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1762738
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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