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PMID: 12907700 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Rapid evolution of male-biased gene expression in Drosophila.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 100 ·No. 17 ·2003-08-19 ·Pages 9894-9

Meiklejohn CD, Parsch J, Ranz JM, Hartl DL

Abstract

A number of genes associated with sexual traits and reproduction evolve at the sequence level faster than the majority of genes coding for non-sex-related traits. Whole genome analyses allow this observation to be extended beyond the limited set of genes that have been studied thus far. We use cDNA microarrays to demonstrate that this pattern holds in Drosophila for the phenotype of gene expression as well, but in one sex only. Genes that are male-biased in their expression show more variation in relative expression levels between conspecific populations and two closely related species than do female-biased genes or genes with sexually monomorphic expression patterns. Additionally, elevated ratios of interspecific expression divergence to intraspecific expression variation among male-biased genes suggest that differences in rates of evolution may be due in part to natural selection. This finding has implications for our understanding of the importance of sexual dimorphism for speciation and rates of phenotypic evolution.

MeSH Terms
Animals Biological Evolution Drosophila/genetics Drosophila melanogaster/genetics Female Gene Expression Profiling Genes, Insect Male Oligonucleotide Array Sequence Analysis Sex Sex Characteristics Species Specificity
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Meiklejohn Colin D
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA. cmeiklejohn@oeb.harvard.edu
Parsch John
Ranz José M
Hartl Daniel L
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.1630690100
Email
cmeiklejohn@oeb.harvard.edu
Published
2003-08-19
Epub
2003-00-07
Pages
9894-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC188344
Subset
IM
Grants
NIGMS NIH HHS · R01 GM060035 · United States
NIGMS NIH HHS · GM 60035 · United States
External Links
PubMed source DOI: 10.1073/pnas.1630690100 PMC Full Text View journal details
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