Home LiteratureArticle Details
PMID: 12885631 Published · ppublish English Comparative Study Evaluation Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Validation Study

The motility of mollicutes.

Biophysical journal ·Vol. 85 ·No. 2 ·2003-08-00 ·Pages 828-42

Wolgemuth CW, Igoshin O, Oster G

Abstract

Recent experiments show that the conformation of filament proteins play a role in the motility and morphology of many different types of bacteria. Conformational changes in the protein subunits may produce forces to drive propulsion and cell division. Here we present a molecular mechanism by which these forces can drive cell motion. Coupling of a biochemical cycle, such as ATP hydrolysis, to the dynamics of elastic filaments enable elastic filaments to propagate deformations that generate propulsive forces. We demonstrate this possibility for two classes of wall-less bacteria called mollicutes: the swimming of helical-shaped Spiroplasma, and the gliding motility of Mycoplasma.

MeSH Terms
Bacterial Physiological Phenomena Computer Simulation Mechanotransduction, Cellular/physiology Models, Biological Models, Chemical Molecular Motor Proteins/chemistry,physiology Motion Mycoplasma/chemistry,physiology Species Specificity Spiroplasma/chemistry,physiology Stress, Mechanical Swimming/physiology Tenericutes/chemistry,physiology
Chemicals
Molecular Motor Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Wolgemuth Charles W
Department of Physiology, University of Connecticut Health Center, Farmington, Connecticut, USA.
Igoshin Oleg
Oster George
References (48)
48 references, click to expand
  1. How myxobacteria glide.
    Curr Biol. 2002 Mar 5;12(5):369-77 PMID: 11882287
  2. Further characterization and in situ localization of chain-like aggregates of the gliding bacteria Myxococcus fulvus and Myxococcus xanthus.
    J Bacteriol. 1997 Feb;179(4):1246-52 PMID: 9023208
  3. Physical principles underlying the transduction of bilayer deformation forces during mechanosensitive channel gating.
    Nat Struct Biol. 2002 Sep;9(9):696-703 PMID: 12172537
  4. Propulsion of Microorganisms by Surface Distortions.
    Phys Rev Lett. 1996 Nov 4;77(19):4102-4104 PMID: 10062388
  5. Dynamic chemical devices: modulation of contraction/extension molecular motion by coupled-ion binding/pH change-induced structural switching.
    Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5201-6 PMID: 11943865
  6. Mechanochemical turbine: a new power cycle.
    Science. 1970 Jan 2;167(3914):45-7 PMID: 5409475
  7. The hydration dynamics of polyelectrolyte gels with applications to cell motility and drug delivery.
    Eur Biophys J. 2004 Apr;33(2):146-58 PMID: 14574521
  8. Open channel structure of MscL and the gating mechanism of mechanosensitive channels.
    Nature. 2002 Aug 29;418(6901):942-8 PMID: 12198539
  9. Molecular mechanism of product storage and release in mucin secretion. II. The role of extracellular Ca++.
    Biorheology. 1987;24(6):625-33 PMID: 3502764
  10. Molecular architecture of bacterial flagellum.
    Q Rev Biophys. 1997 Feb;30(1):1-65 PMID: 9134575
  11. Molecular mechanism of mucin secretion: I. The role of intragranular charge shielding.
    J Dent Res. 1987 Feb;66(2):506-8 PMID: 3476567
  12. How nematode sperm crawl.
    J Cell Sci. 2002 Jan 15;115(Pt 2):367-84 PMID: 11839788
  13. Do cyanobacteria swim using traveling surface waves?
    Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8340-3 PMID: 8710872
  14. Control of cell shape in bacteria: helical, actin-like filaments in Bacillus subtilis.
    Cell. 2001 Mar 23;104(6):913-22 PMID: 11290328
  15. Asymmetric cell division in B. subtilis involves a spiral-like intermediate of the cytokinetic protein FtsZ.
    Cell. 2002 Apr 19;109(2):257-66 PMID: 12007411
  16. Cytoskeletons in prokaryotes.
    Cell Biol Int. 2003;27(5):429-38 PMID: 12758091
  17. Electron microscopic studies of three gliding Mycoplasmas, Mycoplasma mobile, M. pneumoniae, and M. gallisepticum, by using the freeze-substitution technique.
    Curr Microbiol. 2002 Jun;44(6):431-4 PMID: 12000994
  18. Attachment organelle formation represented by localization of cytadherence proteins and formation of the electron-dense core in wild-type and mutant strains of Mycoplasma pneumoniae.
    J Bacteriol. 2003 Feb;185(3):1082-91 PMID: 12533484
  19. Movement on the cell surface of the gliding bacterium, Mycoplasma mobile, is limited to its head-like structure.
    FEMS Microbiol Lett. 2002 Oct 8;215(2):285-9 PMID: 12399048
  20. Intracellular, periodic structures in the gliding bacterium Myxococcus xanthus.
    J Bacteriol. 1977 Nov;132(2):666-72 PMID: 410797
  21. Motility modes of Spiroplasma melliferum BC3: a helical, wall-less bacterium driven by a linear motor.
    Mol Microbiol. 2003 Feb;47(3):657-69 PMID: 12535068
  22. Molecular basis of mechanotransduction in living cells.
    Physiol Rev. 2001 Apr;81(2):685-740 PMID: 11274342
  23. Equilibrium mechanochemistry of collagen fibers.
    Biochemistry. 1969 Sep;8(9):3628-37 PMID: 5387526
  24. Role of Ca2+/K+ ion exchange in intracellular storage and release of Ca2+.
    Nature. 1998 Oct 29;395(6705):908-12 PMID: 9804425
  25. Motility powered by supramolecular springs and ratchets.
    Science. 2000 Apr 7;288(5463):95-100 PMID: 10753126
  26. Rubber-like elasticity and volume changes in the isolated spasmoneme of giant Zoothamnium sp. under Ca2+-induced contraction.
    Biophys J. 1999 Feb;76(2):993-1000 PMID: 9916030
  27. Sodium-coupled motility in a swimming cyanobacterium.
    J Bacteriol. 1987 Aug;169(8):3429-34 PMID: 3112121
  28. Micro-video study of moving bacterial flagellar filaments. III. Cyclic transformation induced by mechanical force.
    J Mol Biol. 1982 Apr 25;156(4):791-806 PMID: 7120394
  29. Motion of an adhesive gel in a swelling gradient: a mechanism for cell locomotion.
    Phys Rev Lett. 2003 Apr 25;90(16):168102 PMID: 12732016
  30. Frozen motion of gliding bacteria outlines inherent features of the motility apparatus.
    Microbiology. 2001 Apr;147(Pt 4):939-47 PMID: 11283289
  31. Envelope structure of Synechococcus sp. WH8113, a nonflagellated swimming cyanobacterium.
    BMC Microbiol. 2001;1:4 PMID: 11329361
  32. Crystal structure of the bacterial cell-division protein FtsZ.
    Nature. 1998 Jan 8;391(6663):203-6 PMID: 9428770
  33. Force and velocity of mycoplasma mobile gliding.
    J Bacteriol. 2002 Apr;184(7):1827-31 PMID: 11889087
  34. Periodic chirality transformations propagating on bacterial flagella.
    Phys Rev Lett. 2002 Sep 9;89(11):118102 PMID: 12225172
  35. Effect of natural amphipathic peptides on viability, membrane potential, cell shape and motility of mollicutes.
    Res Microbiol. 1997 Feb;148(2):163-75 PMID: 9765797
  36. Rotary protein motors.
    Trends Cell Biol. 2003 Mar;13(3):114-21 PMID: 12628343
  37. Protein friction exerted by motor enzymes through a weak-binding interaction.
    J Theor Biol. 1991 May 21;150(2):193-200 PMID: 1832473
  38. Construction of bacterial flagella.
    Nature. 1975 May 8;255(5504):121-4 PMID: 1128677
  39. Normal-to-curly flagellar transitions and their role in bacterial tumbling. Stabilization of an alternative quaternary structure by mechanical force.
    J Mol Biol. 1977 May 5;112(1):1-30 PMID: 328893
  40. Bistable helices.
    Phys Rev Lett. 2000 Feb 14;84(7):1631-4 PMID: 11017585
  41. Bacterial motility: how do pili pull?
    Curr Biol. 2000 Nov 2;10(21):R777-80 PMID: 11084348
  42. Bacterial gliding motility: multiple mechanisms for cell movement over surfaces.
    Annu Rev Microbiol. 2001;55:49-75 PMID: 11544349
  43. Energy transduction in the sodium F-ATPase of Propionigenium modestum.
    Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):4924-9 PMID: 10220395
  44. Mollicutes-wall-less bacteria with internal cytoskeletons.
    J Struct Biol. 1998 Dec 15;124(2-3):244-56 PMID: 10049810
  45. Structure of the bacterial flagellar protofilament and implications for a switch for supercoiling.
    Nature. 2001 Mar 15;410(6826):331-7 PMID: 11268201
  46. Effect of cellular filamentation on adventurous and social gliding motility of Myxococcus xanthus.
    Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15178-83 PMID: 10611358
  47. Crystal structure of Escherichia coli MscS, a voltage-modulated and mechanosensitive channel.
    Science. 2002 Nov 22;298(5598):1582-7 PMID: 12446901
  48. A bacterial linear motor: cellular and molecular organization of the contractile cytoskeleton of the helical bacterium Spiroplasma melliferum BC3.
    Mol Microbiol. 2001 Aug;41(4):827-48 PMID: 11532147
Article Info
Journal
Biophysical journal
Abbr.
Biophys J
ISSN
0006-3495
DOI
10.1016/S0006-3495(03)74523-8
Published
2003-08-00
Pages
828-42
Language
English
Region
United States
NLM ID
0370626
PMCID
PMC1303205
Subset
IM
Grants
NIGMS NIH HHS · R01 GM059875 · United States
NIGMS NIH HHS · GM59875-02 · United States
External Links
PubMed source DOI: 10.1016/S0006-3495(03)74523-8 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2