The hydration dynamics of polyelectrolyte gels with applications to cell motility and drug delivery.

European biophysics journal : EBJ ·Vol. 33 ·No. 2 ·2004-04-00 ·Pages 146-58

Wolgemuth CW, Mogilner A, Oster G

Abstract

We combine the physics of gels with the hydrodynamics of two-phase fluids to construct a set of equations that describe the hydration dynamics of polyelectrolyte gels. We use the model to address three problems. First, we express the effective diffusion constants for neutral and charged spherically distributed gels in terms of microscopic parameters. Second, we use the model to describe the locomotion of nematode sperm cells. Finally, we describe the swelling dynamics of polyelectrolyte gels used for drug release.

MeSH Terms

Animals Computer Simulation Delayed-Action Preparations/chemistry Drug Delivery Systems/methods Elasticity Electrolytes/chemistry Hydrogels/chemistry Kinetics Male Models, Biological Models, Chemical Molecular Motor Proteins/chemistry,physiology Nematoda Phase Transition Sperm Motility/physiology Spermatozoa/chemistry,physiology Water/chemistry

Chemicals

Delayed-Action Preparations Electrolytes Hydrogels Molecular Motor Proteins Water

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Wolgemuth Charles W

Departments of Molecular & Cellular Biology and ESPM, University of California, Berkeley, CA 94720-3112, USA.

Mogilner Alexander

Oster George

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13 references, click to expand

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Article Info

Journal

European biophysics journal : EBJ

Abbr.

Eur Biophys J

ISSN

0175-7571

DOI

10.1007/s00249-003-0344-5

Published

2004-04-00

Epub

2003-00-23

Pages

146-58

Language

English

Region

Germany

NLM ID

8409413

Subset

External Links

PubMed source DOI: 10.1007/s00249-003-0344-5 View journal details

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The hydration dynamics of polyelectrolyte gels with applications to cell motility and drug delivery.

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