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PMID: 12878706 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Neuronal migration from the forebrain to the olfactory bulb requires a new attractant persistent in the olfactory bulb.

The Journal of neuroscience : the official journal of the Society for Neuroscience ·Vol. 23 ·No. 16 ·2003-07-23 ·Pages 6651-9

Liu G, Rao Y

Abstract

Interneurons in the olfactory bulb (OB) are generated not only in the developing embryo but also throughout the postnatal life of mammals from neuronal precursor cells migrating from the anterior subventricular zone (SVZa) of the mammalian forebrain. We discovered that the OB secretes a diffusible activity that attracts these neuronal precursor cells. The attractive activity is present in specific layers in the OB, including the glomerular layer but not the granule cell layer. The attractive activity and the neuronal responsiveness persist from embryonic through neonatal to adult stages. Removal of the rostral OB significantly reduces SVZa migration toward the OB, an effect that can be rescued by a transplant of the OB but not by that of the neocortex. The activity in the OB is not mimicked by the known attractants. These results provide an explanation for the continuous migration of SVZa neurons toward the OB, demonstrate an important role of the OB in neuronal migration, and reveal the existence of a new chemoattractant.

MeSH Terms
Animals Cell Movement/drug effects,physiology Cells, Cultured Chemotactic Factors/pharmacology,physiology Coculture Techniques Diffusion Gestational Age Neurons/cytology,drug effects,physiology Olfactory Bulb/cytology,embryology,metabolism Prosencephalon/cytology,embryology,physiology Rats Rats, Sprague-Dawley Signal Transduction/physiology Stem Cells/cytology,drug effects,physiology
Chemicals
Chemotactic Factors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Liu Guofa
Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Rao Yi
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Article Info
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Abbr.
J Neurosci
ISSN
1529-2401
Published
2003-07-23
Pages
6651-9
Language
English
Region
United States
NLM ID
8102140
PMCID
PMC6740643
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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