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PMID: 10432110 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Directional guidance of neuronal migration in the olfactory system by the protein Slit.

Nature ·Vol. 400 ·No. 6742 ·1999-07-22 ·Pages 331-6

Wu W, Wong K, Chen J, Jiang Z, Dupuis S, Wu JY, Rao Y

Abstract

Although cell migration is crucial for neural development, molecular mechanisms guiding neuronal migration have remained unclear. Here we report that the secreted protein Slit repels neuronal precursors migrating from the anterior subventricular zone in the telencephalon to the olfactory bulb. Our results provide a direct demonstration of a molecular cue whose concentration gradient guides the direction of migrating neurons. They also support a common guidance mechanism for axon projection and neuronal migration and suggest that Slit may provide a molecular tool with potential therapeutic applications in controlling and directing cell migration.

MeSH Terms
Animals Cell Line Chemotactic Factors/metabolism,physiology Chemotaxis/physiology Coculture Techniques Culture Techniques Drosophila Proteins Nerve Tissue Proteins/metabolism,physiology Neurons/physiology Olfactory Bulb/cytology,embryology Rats Rats, Sprague-Dawley Receptors, Immunologic/physiology Septum Pellucidum/cytology,embryology Telencephalon/cytology,embryology
Chemicals
Chemotactic Factors Drosophila Proteins Nerve Tissue Proteins Receptors, Immunologic roundabout protein sli protein, Drosophila
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Wu W
Laboratory of Molecular Neurobiology, Shanghai Research Center for the Life Sciences, The Chinese Academy of Sciences.
Wong K
Chen J
Jiang Z
Dupuis S
Wu J Y
Rao Y
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Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
DOI
10.1038/22477
Published
1999-07-22
Pages
331-6
Language
English
Region
England
NLM ID
0410462
PMCID
PMC2041931
Subset
IM
Grants
NEI NIH HHS · R01 EY014576-03 · United States
NIGMS NIH HHS · R01 GM070967-02 · United States
NCI NIH HHS · R01 CA114197-01A2 · United States
NEI NIH HHS · R01 EY014576 · United States
NIGMS NIH HHS · R01 GM070967 · United States
NCI NIH HHS · R01 CA114197 · United States
Corrections
CommentIn
PMID: 10432106
External Links
PubMed source DOI: 10.1038/22477 PMC Full Text View journal details
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