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PMID: 12848337 Published · ppublish English Journal Article Review

Molecular evolution of nucleoside diphosphate kinase genes: conserved core structures and multiple-layered regulatory regions.

Journal of bioenergetics and biomembranes ·Vol. 35 ·No. 1 ·2003-02-00 ·Pages 7-18

Ishikawa N, Shimada N, Takagi Y, Ishijima Y, Fukuda M, Kimura N

Abstract

Genomic data regarding the nucleoside diphosphate (NDP) kinase genes have been accumulated from diverged phyla. Comparison of their regulatory sequences have shed light on the multiple facets of gene regulation systems. Phylogenetic studies, including CpG island and intron-mapping, and homologous sequence comparison, have suggested that the regions of the major mammalian genes, the ortholog (rat alpha or nm23-H2) and its paralog (rat beta or nm23-H1), have been constructed by a stepwise gain and loss of alien genes resulting in "multiple-layered" regulatory systems. They contain representative cis-elements for the constitutive, stage/lineage-specific, and early response expression. These elements' binding capacities to nuclear proteins were confirmed by electrophoretic mobility shift assay. Further, these regulatory systems generate heterogeneous mRNA at the 5' untranslated region, which influences their own translation efficiencies. In terms of this process, the transcription system would control another layer of gene expression: posttranscriptional (translational) regulation.

MeSH Terms
Amino Acid Sequence Animals Conserved Sequence/genetics Evolution, Molecular Gene Expression Regulation, Enzymologic/physiology Humans Molecular Sequence Data Nucleoside-Diphosphate Kinase/chemistry,genetics,metabolism Regulatory Sequences, Nucleic Acid/genetics Sequence Alignment Sequence Analysis, Protein Sequence Homology, Amino Acid Species Specificity Structure-Activity Relationship
Chemicals
Nucleoside-Diphosphate Kinase
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Ishikawa Naoshi
Cellular Signaling Research Group, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakaecho, Itabashi-ku, Tokyo 173-0015, Japan. naoshi@tmig.or.jp
Shimada Nobuko
Takagi Yohko
Ishijima Yasushi
Fukuda Mitsugu
Kimura Narimichi
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Article Info
Journal
Journal of bioenergetics and biomembranes
Abbr.
J Bioenerg Biomembr
ISSN
0145-479X
DOI
10.1023/a:1023433504713
Email
naoshi@tmig.or.jp
Published
2003-02-00
Pages
7-18
Language
English
Region
United States
NLM ID
7701859
Subset
IM
Corrections
CommentIn
PMID: 12848336
External Links
PubMed source DOI: 10.1023/a:1023433504713 View journal details
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