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PMID: 1282335 Published · ppublish English Journal Article Review

Relationships between the rapid axonal transport of newly synthesized proteins and membranous organelles.

Molecular neurobiology ·Vol. 6 ·No. 2-3 ·1992-00-00 ·Pages 285-300

Smith RS, Snyder RE

Abstract

Rapid axonal transport is generally viewed as being exactly analogous to the secretory process in nonneuronal cells. The cell biology of rapid axonal transport is reviewed, the central concern being to explore those aspects that do not fit into the general secretory model and which may thus represent specific neuronal adaptations. Particular attention is paid to the relationship between the transport of newly synthesized proteins and of the membranous organelles that act as carriers. Sites in the transport sequence at which the behavior of axonal transport may differ from the secretory model are at the initiation of axonal transport at the trans-side of the Golgi apparatus, within the axon where molecules are deposited from the moving phase to a stationary phase, and at nerve terminals or axonal lesions where transport reversal takes place.

MeSH Terms
Animals Axonal Transport Axons/metabolism Cell Membrane/metabolism Kinetics Nerve Tissue Proteins/biosynthesis,metabolism Neurons/metabolism Organelles/metabolism
Chemicals
Nerve Tissue Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Smith R S
Department of Anatomy and Cell Biology, University of Alberta, Edmonton, Canada.
Snyder R E
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Article Info
Journal
Molecular neurobiology
Abbr.
Mol Neurobiol
ISSN
0893-7648
DOI
10.1007/BF02780558
Published
1992-00-00
Pages
285-300
Language
English
Region
United States
NLM ID
8900963
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02780558 View journal details
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