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PMID: 12739134 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

The histone H4 gene of Plasmodium falciparum is developmentally transcribed in asexual parasites.

Parasitology research ·Vol. 90 ·No. 5 ·2003-08-00 ·Pages 387-9

Przyborski JM, Bartels K, Lanzer M, Andrews KT

Abstract

Histones are abundant nuclear core proteins that are present in all eukararyotes and are responsible for linking chromosomes and packaging them into tight chromatin aggregates. The histone H2A, H2B, and H3 genes and a partial sequence of the histone H4 gene from Plasmodium falciparum have been previously identified and share a high level of nucleotide sequence identity. In this study, we compare the histone H4 sequence of the human malaria P. falciparum with the sequences of two mouse malarias, Plasmodium berghei and Plasmodium yoelii, revealing at least 91% identity at the nucleotide level and 100% conservation at the amino acid level. Furthermore, we show the P. falciparum histone H4 is developmentally transcribed in late stage asexual parasites, completing the transcription profile for the genes comprising the histone octamer of P. falciparum and adding support to suggestions that a novel histone mRNA control mechanism exists in this parasite.

MeSH Terms
Animals Base Sequence Blotting, Northern Cloning, Molecular Gene Expression Profiling Histones/genetics Molecular Sequence Data Plasmodium berghei/genetics Plasmodium falciparum/genetics,growth & development Plasmodium yoelii/genetics Polymerase Chain Reaction RNA, Messenger/genetics,metabolism RNA, Protozoan/genetics,metabolism Sequence Homology, Nucleic Acid Species Specificity Transcription, Genetic
Chemicals
Histones RNA, Messenger RNA, Protozoan
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Przyborski Jude M
Abteilung Parasitologie, Hygiene-Institut, Im Neuenheimer Feld 324, 69120, Heidelberg, Germany.
Bartels Kathrin
Lanzer Michael
Andrews Katherine T
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Article Info
Journal
Parasitology research
Abbr.
Parasitol Res
ISSN
0932-0113
DOI
10.1007/s00436-003-0874-x
Published
2003-08-00
Epub
2003-00-09
Pages
387-9
Language
English
Region
Germany
NLM ID
8703571
Subset
IM
External Links
PubMed source DOI: 10.1007/s00436-003-0874-x View journal details
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