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PMID: 1271525 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Neurovirulence and induction of hydrocephalus with parental, mutant, and revertant strains of measles virus.

Journal of virology ·Vol. 18 ·No. 2 ·1976-05-00 ·Pages 809-11

Breschkin AM, Haspel MV, Rapp F

Abstract

The relationship between neurovirulence and induction of hydrocephalus was investigated for a measles virus temperature-sensitive mutant and its revertant. The revertant regained the neurovirulence of the parental strain. At appropriate doses the parental, mutant, and revertant strains induced hydrocephalus.

MeSH Terms

Animals Animals, Newborn Brain/microbiology Cricetinae Hydrocephalus/etiology Measles virus/growth & development,pathogenicity Mutation Temperature Virulence

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Breschkin A M

Haspel M V

Rapp F

References (9)

9 references, click to expand

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J Virol. 1975 Jul;16(1):192-202 PMID: 805848
Measles virus: an unwanted variant causing hydrocephalus.
Science. 1975 Feb 7;187(4175):450-1 PMID: 1111114
Experimental measles encephalitis: a genetic analysis.
Infect Immun. 1975 Oct;12(4):785-90 PMID: 1193715
Genetic manipulation of reovirus--a model for modification of disease.
N Engl J Med. 1972 Nov 16;287(20):1026-33 PMID: 4346708
Virus-induced hydrocephalus: development of aqueductal stenosis in hamsters after mumps infection.
Science. 1967 Sep 1;157(3792):1066-7 PMID: 5340983
Isolation and preliminary characterization of temperature-sensitive mutants of measles virus.
J Virol. 1975 Oct;16(4):1000-9 PMID: 51932
Activation of a latent measles virus infection in hamster cells.
J Virol. 1973 Oct;12(4):690-5 PMID: 4204692
Relationship between neurovirulence and temperature sensitivity of an attenuated western equine encephalitis virus.
Arch Gesamte Virusforsch. 1971;35(2):242-50 PMID: 5137591
Hydrocephalus following viral infection: the pathology of aqueductal stenosis developing after experimental mumps virus infection.
J Neuropathol Exp Neurol. 1968 Oct;27(4):591-606 PMID: 5687756

Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.18.2.809-811.1976

Published

1976-05-00

Pages

809-11

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC515613

Subset

External Links

PubMed source DOI: 10.1128/JVI.18.2.809-811.1976 PMC Full Text View journal details

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Neurovirulence and induction of hydrocephalus with parental, mutant, and revertant strains of measles virus.

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