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PMID: 12649489 Published · ppublish English Journal Article Review

Rube Goldberg goes (ribo)nuclear? Molecular switches and sensors made from RNA.

RNA (New York, N.Y.) ·Vol. 9 ·No. 4 ·2003-04-00 ·Pages 377-83

Silverman SK

Abstract

Switches and sensors play important roles in our everyday lives. The chemical properties of RNA make it amenable for use as a switch or sensor, both artificially and in nature. This review focuses on recent advances in artificial RNA switches and sensors. Researchers have been applying classical biochemical principles such as allostery in elegant ways that are influencing the development of biosensors and other applications. Particular attention is given here to allosteric ribozymes (aptazymes) that are regulated by small organic molecules, by proteins, or by oligonucleotides. Also discussed are ribozymes whose activities are controlled by various nonallosteric strategies.

MeSH Terms
Allosteric Regulation Bacterial Physiological Phenomena Biosensing Techniques Forecasting Genes, Switch Oligonucleotides/metabolism RNA/physiology RNA, Catalytic/metabolism Signal Transduction/physiology
Chemicals
Oligonucleotides RNA, Catalytic RNA
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Silverman Scott K
Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA. scott@scs.uiuc.edu
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Article Info
Journal
RNA (New York, N.Y.)
Abbr.
RNA
ISSN
1355-8382
DOI
10.1261/rna.2200903
Email
scott@scs.uiuc.edu
Published
2003-04-00
Pages
377-83
Language
English
Region
United States
NLM ID
9509184
PMCID
PMC1370404
Subset
IM
External Links
PubMed source DOI: 10.1261/rna.2200903 PMC Full Text View journal details
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