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PMID: 12110901 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review

RNA interference.

Nature ·Vol. 418 ·No. 6894 ·2002-07-11 ·Pages 244-51

Hannon GJ

Abstract

A conserved biological response to double-stranded RNA, known variously as RNA interference (RNAi) or post-transcriptional gene silencing, mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes. RNAi has been cultivated as a means to manipulate gene expression experimentally and to probe gene function on a whole-genome scale.

MeSH Terms
Animals Gene Silencing Genetic Techniques Genome Models, Genetic RNA Processing, Post-Transcriptional RNA, Double-Stranded/chemistry,genetics,metabolism
Chemicals
RNA, Double-Stranded
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Hannon Gregory J
Cold Spring Harbour Laboratory, New York 11724, USA. hannon@cshl.org
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
Published
2002-07-11
Pages
244-51
Language
English
Region
England
NLM ID
0410462
Subset
IM
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