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PMID: 12627395 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Structural evidence for common functions and ancestry of the reovirus and adenovirus attachment proteins.

Reviews in medical virology ·Vol. 13 ·No. 2 ·2003-00-00 ·Pages 123-32

Stehle T, Dermody TS

Abstract

The crystal structure of the reovirus attachment protein, sigma1, reveals a fibre-like structure that is remarkably similar to that of the adenovirus attachment protein, fibre. Both proteins are trimers with head-and-tail morphology. They share unique domain structures and functional properties including defined regions of flexibility within the tail and an unusual symmetry mismatch with the pentameric viral capsid protein into which they are inserted. Moreover, the receptors for reoviruses and adenoviruses, junctional adhesion molecule 1 and coxsackievirus and adenovirus receptor, respectively, also share key structural and functional properties. Although reoviruses and adenoviruses belong to different virus families and have few properties in common, the observed similarities between sigma1 and fibre point to a conserved mechanism of attachment and an ancient evolutionary relationship.

MeSH Terms
Adenoviridae/genetics,physiology Animals Capsid Proteins/chemistry,genetics,metabolism Cell Adhesion Molecules/chemistry,genetics,metabolism Coxsackie and Adenovirus Receptor-Like Membrane Protein Evolution, Molecular Humans Junctional Adhesion Molecules Mice Models, Molecular Receptors, Virus/chemistry,genetics,metabolism Reoviridae/genetics,physiology Viral Nonstructural Proteins/chemistry,genetics,metabolism
Chemicals
CLMP protein, human CLMP protein, mouse Capsid Proteins Cell Adhesion Molecules Coxsackie and Adenovirus Receptor-Like Membrane Protein Junctional Adhesion Molecules Receptors, Virus Viral Nonstructural Proteins hexon capsid protein, Adenovirus sigma 1NS protein, Reovirus
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Stehle Thilo
Laboratory of Developmental Immunology and Renal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. tstehle@partners.org
Dermody Terence S
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Article Info
Journal
Reviews in medical virology
Abbr.
Rev Med Virol
ISSN
1052-9276
DOI
10.1002/rmv.379
Email
tstehle@partners.org
Published
2003-00-00
Pages
123-32
Language
English
Region
England
NLM ID
9112448
PMCID
PMC7169122
Subset
IM
Grants
NIAID NIH HHS · AI38296 · United States
NIAID NIH HHS · AI45716 · United States
External Links
PubMed source DOI: 10.1002/rmv.379 PMC Full Text View journal details
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