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PMID: 12626765 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Persistence and brain circuitry.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 100 ·No. 6 ·2003-03-18 ·Pages 3479-84

Gusnard DA, Ollinger JM, Shulman GL, Cloninger CR, Price JL, Van Essen DC, Raichle ME

Abstract

The orbitofrontal and adjacent medial prefrontal cortex may play an important role in normal social functioning and affect modulation. Recent anatomical studies of this area of the prefrontal cortex have demonstrated a striking correspondence of fine-grained architectonic partitioning schemes in humans and nonhuman primates. This finding allows neurophysiological recording and anatomical connectivity data in animals to be considered together with functional imaging data and lesion studies in humans. In a functional MRI study, we show that individual differences in Persistence, a dimensional trait assessed with a seven-factor personality model, may be linked to specific areas in the lateral orbital and medial prefrontal cortex and the ventral striatum. These areas are part of an anatomical circuit that has been defined in nonhuman primates and has been implicated in functions related to behavioral persistence. These findings represent a fresh approach to linking normal individual differences in personality and behavior to specific neuronal structures and subsystems.

MeSH Terms
Adult Animals Female Haplorhini/physiology,psychology Humans Magnetic Resonance Imaging Male Personality Prefrontal Cortex/anatomy & histology,physiology Social Behavior Species Specificity
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Gusnard Debra A
Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA. gusnard@npg.wustl.edu
Ollinger John M
Shulman Gordon L
Cloninger C Robert
Price Joseph L
Van Essen David C
Raichle Marcus E
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.0538050100
Email
gusnard@npg.wustl.edu
Published
2003-03-18
Epub
2003-00-07
Pages
3479-84
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC152318
Subset
IM
Grants
NIDA NIH HHS · DA 07261 · United States
NINDS NIH HHS · NS 06833 · United States
NINDS NIH HHS · P50 NS006833 · United States
NIMH NIH HHS · P20 MH062130 · United States
NIDCD NIH HHS · R01 DC000093 · United States
NIMH NIH HHS · R01 MH060974 · United States
NIMH NIH HHS · MH 62130 · United States
NIDA NIH HHS · T32 DA007261 · United States
NIMH NIH HHS · MH 60974 · United States
NIMH NIH HHS · R01 MH060879 · United States
NIDCD NIH HHS · DC 00093 · United States
External Links
PubMed source DOI: 10.1073/pnas.0538050100 PMC Full Text View journal details
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