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PMID: 12578964 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 100 ·No. 4 ·2003-02-18 ·Pages 1723-8

Soderling SH, Langeberg LK, Soderling JA, Davee SM, Simerly R, Raber J, Scott JD

Abstract

The Scar/WAVE family of scaffolding proteins organize molecular networks that relay signals from the GTPase Rac to the actin cytoskeleton. The WAVE-1 isoform is a brain-specific protein expressed in variety of areas including the regions of the hippocampus and the Purkinje cells of the cerebellum. Targeted disruption of the WAVE-1 gene generated mice with reduced anxiety, sensorimotor retardation, and deficits in hippocampal-dependent learning and memory. These sensorimotor and cognitive deficits are analogous to the symptoms of patients with 3p-syndrome mental retardation who are haploinsufficient for WRP/MEGAP, a component of the WAVE-1 signaling network. Thus WAVE-1 is required for normal neural functioning.

MeSH Terms
Animals Blotting, Northern Blotting, Southern Chromosomes, Artificial, Bacterial Cloning, Molecular Immunohistochemistry In Situ Hybridization Learning Memory Mice Mice, Inbred C57BL Mice, Knockout Microfilament Proteins/genetics,physiology Motor Activity/genetics Polymerase Chain Reaction Wiskott-Aldrich Syndrome Protein Family
Chemicals
Microfilament Proteins Wasf1 protein, mouse Wiskott-Aldrich Syndrome Protein Family
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Soderling Scott H
Howard Hughes Medical Institute, Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA. scott@ohsu.edu
Langeberg Lorene K
Soderling Jacquelyn A
Davee Stephen M
Simerly Richard
Raber Jacob
Scott John D
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.0438033100
Email
scott@ohsu.edu
Published
2003-02-18
Epub
2003-00-10
Pages
1723-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC149900
Subset
IM
Grants
NIDDK NIH HHS · P01 DK044239 · United States
NIA NIH HHS · AG20079 · United States
NIDDK NIH HHS · DK44239 · United States
External Links
PubMed source DOI: 10.1073/pnas.0438033100 PMC Full Text View journal details
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