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PMID: 11248549 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Regulating cellular actin assembly.

Current opinion in cell biology ·Vol. 13 ·No. 2 ·2001-04-00 ·Pages 158-66

Bear JE, Krause M, Gertler FB

Abstract

Cellular actin assembly is tightly regulated. The study of pathogen motility has led to the identification of several cellular factors that are critical for controlling this process. Pathogens such as Listeria require Ena/VASP and Arp2/3 proteins to translate actin polymerization into movement. Recent work has extended these observations and uncovered some similarities and surprising differences in the way cells and pathogens utilize the actin cytoskeleton.

MeSH Terms
Actin-Related Protein 2 Actins/metabolism Animals Bacterial Proteins/metabolism Cytoskeletal Proteins Cytoskeleton/metabolism DNA-Binding Proteins/metabolism Listeria monocytogenes/physiology Membrane Proteins/metabolism Microfilament Proteins/metabolism Protein Binding Shigella flexneri/physiology Transcription Factors/metabolism Wiskott-Aldrich Syndrome Protein Family
Chemicals
Actin-Related Protein 2 Actins Bacterial Proteins Cytoskeletal Proteins DNA-Binding Proteins Membrane Proteins Microfilament Proteins Transcription Factors Wiskott-Aldrich Syndrome Protein Family virG protein, Shigella flexneri actA protein, Listeria monocytogenes
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Bear J E
Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
Krause M
Gertler F B
Article Info
Journal
Current opinion in cell biology
Abbr.
Curr Opin Cell Biol
ISSN
0955-0674
DOI
10.1016/s0955-0674(00)00193-9
Published
2001-04-00
Pages
158-66
Language
English
Region
England
NLM ID
8913428
Subset
IM
Grants
NIGMS NIH HHS · GM20267-01 · United States
NIGMS NIH HHS · GM58801 · United States
External Links
PubMed source DOI: 10.1016/s0955-0674(00)00193-9 View journal details
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