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PMID: 12473749 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Associations between human disease genes and overlapping gene groups and multiple amino acid runs.

Karlin S, Chen C, Gentles AJ, Cleary M

Abstract

Overlapping gene groups (OGGs) arise when exons of one gene are contained within the introns of another. Typically, the two overlapping genes are encoded on opposite DNA strands. OGGs are often associated with specific disease phenotypes. In this report, we identify genes with OGG architecture and genes encoding multiple long amino acid runs and examine their relations to diseases. OGGs appear to be susceptible to genomic rearrangements as happens commonly with the loci of the DiGeorge syndrome on human chromosome 22. We also examine the degree of conservation of OGGs between human and mouse. Our analyses suggest that (i) a high proportion of genes in OGG regions are disease-associated, (ii) genomic rearrangements are likely to occur within OGGs, possibly as a consequence of anomalous sequence features prevalent in these regions, and (iii) multiple amino acid runs are also frequently associated with pathologies.

MeSH Terms
Amino Acids/genetics Animals Chromosomes, Human, Pair 22 DiGeorge Syndrome/genetics Exons Gene Rearrangement Genes, Overlapping Humans Introns Mice
Chemicals
Amino Acids
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Karlin Samuel
Departments of Mathematics and Pathology, Stanford University, Stanford, CA 94305, USA. karlin@math.stanford.edu
Chen Chingfer
Gentles Andrew J
Cleary Michael
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
Published
2002-12-24
Epub
2002-00-09
Pages
17008-13
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC139260
Subset
IM
Grants
NIGMS NIH HHS · R01 GM010452 · United States
NIGMS NIH HHS · 5R01GM10452-38 · United States
NHGRI NIH HHS · 5R01HG00335-15 · United States
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